216064-48-1

• 常用中文名：N-boc-5-羟基-1,2,3,4-四氢异喹啉
• 常用英文名：2-Methyl-2-Propanyl 5-Hydroxy-3,4-Dihydro-2(1H)-Isoquinolinecarboxylate
• CAS号：216064-48-1
• 分子式：C₁₄H₁₉NO₃
• 分子量：249.306
• 发布时间：2018-12-25 17:07:30
• 更新时间：2024-01-10 11:58:20

名称

• 中文名: 叔-丁基 5-羟基-3,4-二氢异喹啉-2(1H)-甲酸
• 英文名: tert-butyl 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
• 中文别名: 5-羟基-3,4-二氢异喹啉-2(1h)-羧酸叔丁酯
• 英文别名: 2-t-butoxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline; 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-hydroxy-, 1,1-dimethylethyl ester; tert-butyl 5-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 2-tert-butoxycarbonyl-5-hydroxy-tetrahydroisoquinoline; 2-Methyl-2-propanyl 5-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate; 5-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; 2-tert-butyloxycarbonyl-5-hydroxy-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 5-hydroxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 378.6±42.0 °C at 760 mmHg
• 分子式: C₁₄H₁₉NO₃
• 分子量: 249.306
• 闪点: 182.7±27.9 °C
• 精确质量: 249.136490
• PSA: 49.77000
• LogP: 2.21
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.558
• 储存条件: 2-8℃，干燥，密封

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933499090

合成路线

24424-99-5 2439-04-5 ~59% 216064-48-1

文献：Takeda Chemical Industries, Ltd. Patent: EP1123918 A1, 2001 ;

24424-99-5 102879-34-5 ~79% 216064-48-1

文献：Watanabe, Toshihiro; Kinoyama, Isao; Takizawa, Kenji; Hirano, Seiko; Shibanuma, Tadao Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 5 p. 672 - 677

102877-50-9 24424-99-5 ~83% 216064-48-1

文献：Fray, M. Jonathan; Allen, Paul; Bradley, Paul R.; Challenger, Clare E.; Closier, Michael; Evans, Tim J.; Lewis, Mark L.; Mathias, John P.; Nichols, Carly L.; Po-Ba, Yvonne M.; Snow, Hayley; Stefaniak, Mark H.; Vuong, Hannah V. Tetrahedron, 2006 , vol. 62, # 29 p. 6869 - 6875

2439-04-5 ~% 216064-48-1

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 24 p. 6293 - 6297

102877-50-9 34619-03-9 ~% 216064-48-1

文献：Tetrahedron Letters, , vol. 38, # 49 p. 8569 - 8572

上下游产品

上游产品  5
24424-99-5 2439-04-5 102877-50-9 102879-34-5
34619-03-9
下游产品  0

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%