88296-62-2

• 常用中文名：群司卡尼
• 常用英文名：Transcainide
• CAS号：88296-62-2
• 分子式：C₂₂H₃₅N₃O₂
• 分子量：373.53200
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-09-26 14:23:00
• 更新时间：2023-10-17 18:28:11
• Transcainide (R 54718) 是具有口服活性的抗心律失常剂。

名称

• 中文名: 群司卡尼
• 英文名: Transcainide

物化性质

• 密度: 1.13g/cm3
• 沸点: 529.4ºC at 760 mmHg
• 分子式: C₂₂H₃₅N₃O₂
• 分子量: 373.53200
• 闪点: 274ºC
• 精确质量: 373.27300
• PSA: 55.81000
• LogP: 2.95250
• 折射率: 1.58

生物活性

• 描述: Transcainide (R 54718) 是具有口服活性的抗心律失常剂。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. R Stroobandt, Evaluation of the efficacy and tolerance of the antiarrhythmic agent transcainide (R 54718). Eur J Clin Pharmacol. 1987;32(5):449-56.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM6060000 CHEMICAL NAME : 4-Piperidinecarboxamide, 4-(dimethylamino)-N-(2,6-dimethylphenyl)-1-(2-hydroxy cyclohexyl)-, trans-(+-)- CAS REGISTRY NUMBER : 88296-62-2 LAST UPDATED : 198910 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C22-H35-N3-O2 MOLECULAR WEIGHT : 373.60 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4830 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 440 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 440 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987