CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
TM6060000
-
CHEMICAL NAME :
-
4-Piperidinecarboxamide, 4-(dimethylamino)-N-(2,6-dimethylphenyl)-1-(2-hydroxy cyclohexyl)-, trans-(+-)-
-
CAS REGISTRY NUMBER :
-
88296-62-2
-
LAST UPDATED :
-
198910
-
DATA ITEMS CITED :
-
4
-
MOLECULAR FORMULA :
-
C22-H35-N3-O2
-
MOLECULAR WEIGHT :
-
373.60
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
4830 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
440 ug/kg
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
1500 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
440 ug/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
-
REFERENCE :
-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
|
