113712-08-6

• 常用中文名：L-精氨酸-7-氨基-4-甲基香豆素二盐酸盐
• 常用英文名：R-AMC,2HCL
• CAS号：113712-08-6
• 分子式：C₁₆H₂₃Cl₂N₅O₃
• 分子量：404.29200
• 相关类别： 生物化工 氨基酸及其衍生物 精氨酸类衍生物
• 发布时间：2018-12-30 19:44:02
• 更新时间：2024-02-18 15:58:26

名称

• 中文名: L-精氨酸-7-氨基-4-甲基香豆素二盐酸盐
• 英文名: l-arginine 7-amido-4-methylcoumarin dihydrochloride
• 英文别名: R-AMC,2HCL; CATHEPSIN H SUBSTRATE II,FLUOROGENIC; ARGININE-AMC 2 HCL; H-L-Arg-AMC*2HCl; H-ARG-AMC HCL; H-ARG-AMC 2 HCI; H-ARG-AMC 2 HCL; L-Arginine7-amido-4-methylcoumarin2HCl; H-Arg-AMC.2HCL

物化性质

• 分子式: C₁₆H₂₃Cl₂N₅O₃
• 分子量: 404.29200
• 精确质量: 403.11800
• PSA: 147.23000
• LogP: 4.19870
• 储存条件:

  密封储存，储存于阴凉、干燥的库房。冷藏温度为-20ºC。

• 稳定性:

  常温常压下稳定，避免与不相容材料，光照接触。与强氧化剂，强酸，强碱反应。

• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：403.117795 Da

  8、标称质量：403 Da

  9、平均质量：404.2915 Da

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：-0.3

  2、 氢键供体数量：5

  3、 氢键受体数量：5

  4、 可旋转化学键数量：6

  5、 互变异构体数量：4

  6、 拓扑分子极性表面积（TPSA）：149

  7、 重原子数量：24

  8、 表面电荷：2

  9、 复杂度：542

  10、同位素原子数量：0

  11、确定原子立构中心数量：1

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：1

• 更多:

  1. 性状：白色或浅棕色结晶性粉末

  2. 密度（g/mL,25℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，28mmHg）：未确定

  7. 折射率(n20/D)：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（mmHg,20ºC）：未确定

  12. 饱和蒸气压（kPa,25ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：不溶于水

MSDS

Name: L-Arginine 7-Amido-4-Methylcoumarin Dihydrochloride Material Safety Data Sheet Synonym: None Known CAS: 113712-08-6 Section 1 - Chemical Product MSDS Name:L-Arginine 7-Amido-4-Methylcoumarin Dihydrochloride Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 113712-08-6 L-Arginine 7-Amido-4-Methylcoumarin Di 98.0 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Use agent most appropriate to extinguish fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Vacuum or sweep up material and place into a suitable, dry disposal container. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 113712-08-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: white to light brown Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Negligible. Specific Gravity/Density: Molecular Formula: C16H21N5O3.2HCl Molecular Weight: 404.29 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Light, dust generation. Incompatibilities with Other Materials: Strong acids, strong bases. Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 113712-08-6 unlisted. LD50/LC50: Not available. Carcinogenicity: L-Arginine 7-Amido-4-Methylcoumarin Dihydrochloride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 113712-08-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 113712-08-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 113712-08-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 安全声明 (欧洲): S24/25