514-53-4

514-53-4结构式

常用中文名：金霉素
常用英文名：Isochlortetracyclinehydrochloride
CAS号：514-53-4
分子式：C₂₂H₂₄Cl₂N₂O₈
分子量：515.34100
相关类别：原料药抗生素类药物四环素类药
发布时间：2018-09-14 11:06:59
更新时间：2024-01-12 16:48:14
Isochlortetracycline 是金霉素 (Chlortetracycline (HY-B1327A)) (广谱抗生素) 的无活性碱性降解产物。

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中文名	金霉素
英文名	(4S,4aS,6S,8aR)-6-[(1S)-7-chloro-4-hydroxy-1-methyl-3-oxo-2-benzofuran-1-yl]-4-(dimethylamino)-1,8a-dihydroxy-3,8-dioxo-4a,5,6,7-tetrahydro-4H-naphthalene-2-carboxamide
英文别名	isochlortetracycline 7-chloro-2,3-indolinedione 7-monochloroisatin 7-chloroindoline-2,3-dione 7-chloro-2,3-dihydro-1H-indole-2,3-dione 7-Chlor-isotetracyclin 7-chloro-1H-benzo[d]azolidine-2,3-dione 7-chloro-isotetracycline 7-chloroisatine 7-chloro isatin

描述	Isochlortetracycline 是金霉素 (Chlortetracycline (HY-B1327A)) (广谱抗生素) 的无活性碱性降解产物。
相关类别	研究领域 >> 感染信号通路 >> 其他 >> 其他
参考文献	[1]. Diana J, et al. Evaluation of the stability of chlortetracycline in granular premixes by monitoring its conversion into degradation products. J Pharm Biomed Anal. 2005 Sep 15;39(3-4):523-30.

密度	1.61g/cm3
沸点	743.1ºC at 760mmHg
熔点	231-236ºC (dec.)
分子式	C₂₂H₂₄Cl₂N₂O₈
分子量	515.34100
闪点	403.2ºC
精确质量	514.09100
PSA	167.46000
LogP	2.07020
储存条件	Amber Vial, -20°C Freezer, Under Inert Atmosphere

Name:	Isochlortetracycline hydrochloride can be used as secondary Material Safety Data Sheet
Synonym:	ISOCTC; 2-Naphthalenecarboxamide, 6-(7-chloro-1,3-dihydro-4-hydroxy-1-methyl-3-oxo-1-benzofuranyl)-4
CAS:	514-53-4

Section 1 - Chemical Product MSDS Name:Isochlortetracycline hydrochloride can be used as secondary Material Safety Data Sheet
Synonym:ISOCTC; 2-Naphthalenecarboxamide, 6-(7-chloro-1,3-dihydro-4-hydroxy-1-methyl-3-oxo-1-benzofuranyl)-4

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
514-53-4	Isochlortetracycline hydrochloride	97	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Moisture sensitive.Light sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Do NOT get water inside containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Provide ventilation. Do not get water inside containers.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Do not allow contact with water. Keep from contact with moist air and steam.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store protected from light.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 514-53-4: Personal Protective Equipment Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: light beige
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 234 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 1:2000 m/v
Specific Gravity/Density: Not available.
Molecular Formula: C22H23ClN2O8.HCl
Molecular Weight: 515.34

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures. Moisture sensitive.
Light sensitive.
Conditions to Avoid:
Incompatible materials, light, moisture, strong oxidants.
Incompatibilities with Other Materials:
Moisture, direct light, oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 514-53-4: QJ1891700 LD50/LC50:
CAS# 514-53-4: Oral, mouse: LD50 = >10 gm/kg.
Carcinogenicity:
Isochlortetracycline hydrochloride - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 514-53-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 514-53-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 514-53-4 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

57-62-5

514-53-4

文献：McCormick et al. Journal of the American Chemical Society, 1957 , vol. 79, p. 2849,2856

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