13838-16-9

• 常用中文名：2-氯-1-(二氟甲氧基)-1,1,2-三氟乙烷
• 常用英文名：2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
• CAS号：13838-16-9
• 分子式：C₃H₂ClF₅O
• 分子量：184.49200
• 发布时间：2018-04-23 08:00:00
• 更新时间：2026-07-01 17:53:08
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名称

• 中文名: 易使宁
• 英文名: enflurane
• 中文别名: 安氟醚; 2-氯-1,1,2-三氟乙基二氟甲基醚; 五氟氯甲乙醚; 恩氟烷 标准品; 2-氯-1,1,2-三氟乙基 二氟甲基 醚; 恩氟烷(安氟醚); 恩氟烷; 氟醚麻醉剂
• 英文别名: ethane,2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro; Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl; Enflurane; compound347; Methylflurether; anestheticcompoundno; MFCD00069095; ohio347; 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; Anesthetic; R-E 235ca2; 2-CHLORO-1-(DIFLUOROMETHOXY)-1,1,2-TRIFLUOROETHANE; ENFLURAN; Inhibitor,Potassium Channel,mass,standd,internal,anaesthetic,volatile,spectrometry,inhibit,Enflurane,KcsA; Anesthetic Compound No; Enflurane (DISCONTINUED); Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro; 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl ether 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane, Enflurane; Compound; Alyrane; (2-chloro-1,1,2-trifluoro-ethoxy)-difluoro-methane; ether,2-chloro-1,1,2-trifluoroethyldifluoromethyl; Ethrane; Enflurane //BP; 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-ethan; 2-CHLORO-1,1,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER; NSC-115944; ENFLUORANE; 2-Chloro-1,1,2-trifluoroethyldifluoromethylether; Efrane; 2-Chloro-1,1,2-difluoroethane, 1-difluoromethoxy; EINECS 237-553-4; Ohio; 2-Chloro-1,1,2-trifluoro-1-difluoromethoxyethane; 4-Chloro-1H,4H-perfluoro(2-oxabutane)

物化性质

• 密度: 1.517
• 沸点: 56 °C
• 分子式: C₃H₂ClF₅O
• 分子量: 184.49200
• 闪点: 56-57°C
• 精确质量: 183.97100
• PSA: 9.23000
• LogP: 2.35280
• 蒸汽压: 272mmHg at 25°C
• 折射率: 1.303
• 储存条件:

  常温密闭，阴凉通风干燥

• 稳定性:

  常温常压下稳定

  避免的物料 氧化物
• 分子结构:

  1、 摩尔折射率：23.24

  2、 摩尔体积（cm³/mol）：123.8

  3、 等张比容（90.2K）：247.0

  4、 表面张力（dyne/cm）：15.8

  5、 极化率（10^-24cm³）：9.21

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:6

  4.可旋转化学键数量:3

  5.互变异构体数量:无

  6.拓扑分子极性表面积9.2

  7.重原子数量:10

  8.表面电荷:0

  9.复杂度:107

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色液体

  2. 密度（g/mL,25/4℃）：1.517

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：56-57

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：-3.5

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：201.88

  15. 临界压力（MPa）：2.980

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：不能拌和的或难以拌和的

毒性和生态

毒理学数据: 1、急性毒性：大鼠口经LD50：5450μL/kg；大鼠皮经LC50/3H：14000ppm/3H，缓慢刺激大鼠眼睛：100mg； 主要的刺激性影响： 在皮肤上面：可能引起发炎； 在眼睛上面：刺激的影响； 2、致敏作用：在人体淋巴细胞撒谎那个测试可产生突变。 生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境 CHEMICAL IDENTIFICATION RTECS NUMBER : KN6800000 CHEMICAL NAME : Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl CAS REGISTRY NUMBER : 13838-16-9 LAST UPDATED : 199712 DATA ITEMS CITED : 39 MOLECULAR FORMULA : C3-H2-Cl-F5-O MOLECULAR WEIGHT : 184.50 WISWESSER LINE NOTATION : GYFXFFOYFF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 1 pph/6H TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume decreased TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5450 uL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14000 ppm/3H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6 mL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 19500 uL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8100 ppm/3H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3900 uL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38800 uL/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 170 ppm/3H/4W-I TOXIC EFFECTS : Liver - other changes Liver - changes in liver weight TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3000 ppm/4H/78W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 16500 ppm/6H SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 20 ppm/8H SEX/DURATION : female 28 day(s) pre-mating female 1-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 1500 ppm/6H SEX/DURATION : female 1-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - other postnatal measures or effects TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 16500 ppm/6H SEX/DURATION : female 11-13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 1 pph/4H SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 10000 ppm/4H SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 10000 ppm/4H SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system TYPE OF TEST : Mutation test systems - not otherwise specified TYPE OF TEST : Sperm Morphology MUTATION DATA TEST SYSTEM : Bird - chicken REFERENCE : ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 12,366,1976 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 566 mg/m3 (75 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,93,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 ppm (3.8 mg/m3) JAN 1993 OEL-BELGIUM:TWA 75 ppm (566 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (15 mg/m3) JAN 1993 OEL-SWEDEN:TWA 10 ppm (80 mg/m3);STEL 20 ppm (150 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ENFLURANE-air:CL 2 ppm/60M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3127 No. of Facilities: 2871 (estimated) No. of Industries: 2 No. of Occupations: 12 No. of Employees: 86214 (estimated) No. of Female Employees: 73439 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9341 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 453 (estimated) No. of Female Employees: 329 (estimated)

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H319
• 警示性声明: P305 + P351 + P338
• 危害码 (欧洲): F,T
• 风险声明 (欧洲): R36
• 安全声明 (欧洲): S23-S26-S36
• 危险品运输编码: UN 3334
• RTECS号: KN6800000
• 海关编码: 2909199090

合成路线

428-96-6 ~% 13838-16-9

文献：Journal of medicinal chemistry, , vol. 15, # 6 p. 604 - 606

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海关

海关编码	2909199090
中文概述	2909199090. 其他无环醚及其卤化衍生物（包括磺化，硝化或亚硝化衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%