74515-40-5

• 常用中文名：Acetamide,2-hydroxy-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• 常用英文名：Acetamide,2-hydroxy-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS号：74515-40-5
• 分子式：C₂₂H₂₅NO₇
• 分子量：415.43600
• 发布时间：2016-06-29 11:08:05
• 更新时间：2024-04-05 20:14:54

名称

• 英文名: 2-hydroxy-N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
• 英文别名: Acetamide,2-hydroxy-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-,(S); 2-hydroxy-n-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; Colchifoline; N-(2-hydroxyacetyl)deacetylcolchicine

物化性质

• 密度: 1.31g/cm3
• 沸点: 768.9ºC at 760 mmHg
• 分子式: C₂₂H₂₅NO₇
• 分子量: 415.43600
• 闪点: 418.8ºC
• 精确质量: 415.16300
• PSA: 103.32000
• LogP: 2.23490
• 折射率: 1.601

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC4010000 CHEMICAL NAME : Acetamide, 2-hydroxy-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy -9-oxobenzo(a)heptale n- 7-yl)-, (S)- CAS REGISTRY NUMBER : 74515-40-5 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C22-H25-N-O7 MOLECULAR WEIGHT : 415.48 WISWESSER LINE NOTATION : T B677 MV&T&J CO1 DO1 EO1 JMV1Q NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1620 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

合成路线

79-14-1 3476-50-4 ~27% 74515-40-5

文献：Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435

64-86-8 ~% 74515-40-5

文献：Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435

186374-95-8 ~% 74515-40-5

文献：Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435

186374-94-7 ~% 74515-40-5

文献：Crielaard, Bart J.; Van Der Wal, Steffen; Le, Huong Thu; Bode, Alois T.L.; Lammers, Twan; Hennink, Wim E.; Schiffelers, Raymond M.; Fens, Marcel H.A.M.; Storm, Gert European Journal of Pharmaceutical Sciences, 2012 , vol. 45, # 4 p. 429 - 435

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