7492-29-7

• 常用中文名：克拉唑仑
• 常用英文名：isoquinazepon
• CAS号：7492-29-7
• 分子式：C₁₈H₁₇ClN₂O
• 分子量：312.79300
• 发布时间：2018-03-11 08:00:00
• 更新时间：2024-02-03 05:18:56

名称

• 中文名: 克拉唑仑
• 英文名: isoquinazepon
• 英文别名: 5,9,10,14b-Tetrahydro-2-chloro-5-methylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one; 41-123; Clazolam; 2-Chloro-5-methyl-5,9,10,14B-tetrahydroisoquino[2,1-D][1,4]benzodiazepin-6(7H)-one; 2-chloro-5-methyl-5,9,10,14b-tetrahydro-benzo[5,6][1,4]diazepino[7,1-a]isoquinolin-6-one; d,l-2-Chlor-5-methyl-5,9,10,14b-tetrahydro-isochino<2,1-d><1,4>benzodiazepin-6(7H)-on; 2-Chloro-5,9,10,14b-tetrahydro-5-methylisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one

物化性质

• 分子式: C₁₈H₁₇ClN₂O
• 分子量: 312.79300
• 精确质量: 312.10300
• PSA: 23.55000
• LogP: 3.26680

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NW6710000 CHEMICAL NAME : Isoquino(2,1-d)(1,4)benzodiazepin-6(7H)-one, 5,9,10,14b-tetrahydro-2-chloro-5-methyl- CAS REGISTRY NUMBER : 7492-29-7 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H17-Cl-N2-O MOLECULAR WEIGHT : 312.82 WISWESSER LINE NOTATION : T C6 B676 KN MVN&TT&J N1 RG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1730 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,163,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 465 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,163,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,163,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 233 mg/kg TOXIC EFFECTS : Behavioral - anticonvulsant REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,777,1968