28837-74-3

• 常用中文名：1H-Indole-2-carboxamide,5-methoxy-N,N-dimethyl-
• 常用英文名：1H-Indole-2-carboxamide,5-methoxy-N,N-dimethyl-
• CAS号：28837-74-3
• 分子式：C₁₂H₁₄N₂O₂
• 分子量：218.25200
• 发布时间：2016-03-29 22:26:39
• 更新时间：2024-01-02 02:14:31

名称

• 英文名: 5-methoxy-N,N-dimethyl-1H-indole-2-carboxamide
• 英文别名: N,N-Dimethyl-5-methoxyindole-2-carboxamide; Indole-2-carboxamide,N,N-dimethyl-5-methoxy; 5-methoxy-indole-2-carboxylic acid dimethylamide

物化性质

• 密度: 1.204g/cm3
• 沸点: 429.8ºC at 760mmHg
• 分子式: C₁₂H₁₄N₂O₂
• 分子量: 218.25200
• 闪点: 213.8ºC
• 精确质量: 218.10600
• PSA: 45.33000
• LogP: 1.87830
• 蒸汽压: 1.36E-07mmHg at 25°C
• 折射率: 1.619

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NL5994488 CHEMICAL NAME : Indole-2-carboxamide, N,N-dimethyl-5-methoxy- CAS REGISTRY NUMBER : 28837-74-3 BEILSTEIN REFERENCE NO. : 0398307 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C12-H14-N2-O2 MOLECULAR WEIGHT : 218.28 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 8,704,1970

合成路线

4382-54-1 124-40-3 ~76% 28837-74-3

文献：WYETH LLC; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek Suhayl; TSOU, Hwei-Ru; ZHANG, Nan; VENKATESAN, Aranapakam M.; DI, Li; KERNS, Edward H. Patent: WO2010/30727 A1, 2010 ; Location in patent: Page/Page column 99-100 ; WO 2010/030727 A1

4382-54-1 ~% 28837-74-3

文献：Pelaprat, Didier; Oberlin, Robert; Le Guen, Irene; Roques, Bernard P.; Pecq, Jean-Bernard Le Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1330 - 1335

62099-65-4 124-40-3 ~% 28837-74-3

文献：Pelaprat, Didier; Oberlin, Robert; Le Guen, Irene; Roques, Bernard P.; Pecq, Jean-Bernard Le Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1330 - 1335

上下游产品

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4382-54-1 124-40-3 62099-65-4
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28837-80-1