6554-11-6

• 常用中文名：1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 常用英文名：1-[4-hydroxy-3-trityloxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS号：6554-11-6
• 分子式：C₄₇H₄₀N₂O₆
• 分子量：728.83
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2017-11-03 16:01:47
• 更新时间：2024-01-09 18:44:38
• 2',5'-双-O-(三苯基甲基)尿苷是尿苷类似物。尿苷具有潜在的抗癫痫作用,其类似物可用于研究抗惊厥和抗焦虑活性,以及开发新的抗高血压药物[1]。

名称

• 英文名: Enzastaurin hcl
• 英文别名: 2',5'-Di-O-trityl-uridin; 2',5'-bis-O-trityluridine; Enzastaurin Hydrochloride; 2',5'-Bis-triphenylmethyl-pyrimidin-ribosid; 2',5'-di-O-trityluridine; 2',5'-ditrityluridine; O2',O5'-ditrityl-uridine

物化性质

• 密度: 1.33g/cm3
• 分子式: C₄₇H₄₀N₂O₆
• 分子量: 728.83
• 精确质量: 728.28900
• PSA: 102.78000
• LogP: 7.18090
• 折射率: 1.705

生物活性

• 描述: 2',5'-双-O-(三苯基甲基)尿苷是尿苷类似物。尿苷具有潜在的抗癫痫作用,其类似物可用于研究抗惊厥和抗焦虑活性,以及开发新的抗高血压药物[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Connolly GP, et al. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999 May;20(5):218-25.

合成路线

76-83-5 58-96-8 ~16% 6554-10-5 4710-75-2 详细

文献：Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255

76-83-5 51600-12-5 ~% 4710-75-2 6554-11-6

文献：Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255

76-83-5 58-96-8 ~31% 6554-10-5 13964-43-7 详细

文献：Rhie; Pfleiderer Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452

76-83-5 58-96-8 ~68% 6554-11-6

文献：Pierra, Claire; Amador, Agnes; Badaroux, Eric; Storer, Richard; Gosselin, Gilles Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 7 p. 991 - 1010

76-83-5 6554-10-5 ~42% 4710-75-2 6554-11-6

文献：Rhie; Pfleiderer Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452

76-83-5 58-96-8 ~38% 4710-75-2 6554-11-6

文献：Auguste, Sandra P.; Young, Douglas W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 395 - 404

14470-28-1 ~% 6554-11-6

文献：Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255

58-96-8 ~% 6554-11-6

文献：Chatelain, Gregory; Debing, Yannick; De Burghgraeve, Tine; Zmurko, Joanna; Saudi, Milind; Rozenski, Jef; Neyts, Johan; Van Aerschot, Arthur European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 249 - 255

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