919-16-4

• 常用中文名：柠檬酸锂
• 常用英文名：lithium citrate
• CAS号：919-16-4
• 分子式：C₆H₅Li₃O₇
• 分子量：209.92300
• 相关类别： 原料药 神经系统用药 抗抑郁、躁狂药
• 发布时间：2018-08-21 09:13:38
• 更新时间：2024-01-02 13:44:22
• 柠檬酸锂可减少卡纳万病患者大脑内过量的N-乙酰天冬氨酸[1]。

名称

• 中文名: 柠檬酸锂
• 英文名: Lithium citrate tribasic tetrahydrate
• 中文别名: 2-羟基-1,2,3-丙三羧酸三锂盐; 枸橼酸锂
• 英文别名: lithium citrate

物化性质

• 密度: 1.12 g/mL at 20 °C
• 沸点: 309.6ºC at 760mmHg
• 分子式: C₆H₅Li₃O₇
• 分子量: 209.92300
• 闪点: 155.2ºC
• 精确质量: 210.05200
• PSA: 140.62000
• 外观性状: 白色结晶粉末
• 储存条件: 室温
• 稳定性: Stable. Incompatible with strong oxidizing agents.
• 水溶解性: H2O: 1 M at 20 °C, clear, colorless

生物活性

• 描述: 柠檬酸锂可减少卡纳万病患者大脑内过量的N-乙酰天冬氨酸[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Mitra Assadi, et al. Lithium citrate reduces excessive intra-cerebral N-acetyl aspartate in Canavan disease. Eur J Paediatr Neurol. 2010 Jul;14(4):354-9.

MSDS

Name: Citric acid trilithium salt tetrahydrate 98% Material Safety Data Sheet Synonym: Lithium citrate tetrahydrate; Trilithium citrate tetrahydrate CAS: 919-16-4 Section 1 - Chemical Product MSDS Name:Citric acid trilithium salt tetrahydrate 98% Material Safety Data Sheet Synonym:Lithium citrate tetrahydrate; Trilithium citrate tetrahydrate Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 919-16-4 Citric acid, trilithium salt tetrahydr 98 unlisted Hazard Symbols: XI Risk Phrases: 36 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: Causes eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 919-16-4: CAS# 6080-58-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: white crystalline powder Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 112 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: 112 deg C Solubility in water: slightly soluble Specific Gravity/Density: Molecular Formula: C6H5O7Li3.4H2O Molecular Weight: 281.97 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, strong oxidants. Incompatibilities with Other Materials: Reducing agents, strong oxidizing agents, bases. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 919-16-4: GE8232000 CAS# 6080-58-6 unlisted. LD50/LC50: Not available. Not available. Carcinogenicity: Trilithium citrate anhydrous - Not listed by ACGIH, IARC, or NTP. Citric acid, trilithium salt tetrahydrate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36 Irritating to eyes. Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 919-16-4: No information available. CAS# 6080-58-6: No information available. Canada CAS# 919-16-4 is listed on Canada's NDSL List. CAS# 919-16-4 is not listed on Canada's Ingredient Disclosure List. CAS# 6080-58-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 919-16-4 is listed on the TSCA inventory. CAS# 6080-58-6 is not on the TSCA Inventory because it is a hydrate. It is considered to be listed if the CAS number for the anhydrous form is on the inventory (40CFR720.3(u)(2)). SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GE8232000 CHEMICAL NAME : Citric acid, trilithium salt CAS REGISTRY NUMBER : 919-16-4 LAST UPDATED : 199701 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C6-H5-O7.3Li MOLECULAR WEIGHT : 209.93 WISWESSER LINE NOTATION : OV1XQVO&1VO &-LI- 3 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 7800 nmol/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,33,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2967 No. of Facilities: 50 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 529 (estimated) No. of Female Employees: 227 (estimated)

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-36
• WGK德国: 3