1106685-61-3

• 常用中文名：(S)-2-(4,6-二甲基嘧啶-2-氧基)-3-甲氧基-3,3-二苯基丙酸甲酯
• 常用英文名：(S)-Methyl 2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoate
• CAS号：1106685-61-3
• 分子式：C₂₃H₂₄N₂O₄
• 分子量：392.44800
• 发布时间：2019-01-03 06:30:01
• 更新时间：2026-09-10 18:29:08

名称

• 中文名: (S)-2-(4,6-二甲基嘧啶-2-氧基)-3-甲氧基-3,3-二苯基丙酸甲酯
• 英文名: (S)-Methyl 2-((4,6-dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoate
• 中文别名: 安贝生坦杂质5; 安倍生坦N-1中间体; 安倍生坦杂质14; 安立生坦杂质5; (ALPHAS)-ALPHA-[(4,6-二甲基-2-嘧啶基)氧基]-BETA-甲氧基-BETA-苯基苯丙酸甲酯
• 英文别名: Ambrisentan PI-6; Methyl (2S)-2-[(4,6-diMethyl-2-pyriMidinyl)oxy]-3-Methoxy-3,3-diphenylpropanoate; benzenepropanoic acid, α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, methyl ester, (αS); Methyl (2S)-2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3; methyl (2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoate; (alphaS)-alpha-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-beta-methoxy-beta-phenylbenzenropanoic acid methyl ester; (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate; Ambrisentan Impurity 14

物化性质

• 分子式: C₂₃H₂₄N₂O₄
• 分子量: 392.44800
• 精确质量: 392.17400
• PSA: 70.54000
• LogP: 3.60400
• 外观性状: 类白色至白色固体

安全

• 海关编码: 2933599090

合成路线

35144-22-0 177036-78-1 ~72% 1106685-61-3

文献：CIPLA LIMITED; KING, Lawrence; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; NAIK, Sanjay; GHAGARE, Maruti; CHIKHALIKAR, Sandip Vasant Patent: WO2013/57468 A1, 2013 ; Location in patent: Page/Page column 21-22 ;

178306-52-0 ~% 1106685-61-3

文献：Reddy, Manne Satyanarayana; Nagaraju, Chakilam; Ramprasad, Achampeta Kodanda Patent: US2011/263854 A1, 2011 ; US 20110263854 A1

178306-47-3 ~% 1106685-61-3

文献：Reddy, Manne Satyanarayana; Nagaraju, Chakilam; Ramprasad, Achampeta Kodanda Patent: US2011/263854 A1, 2011 ; US 20110263854 A1

178306-51-9 ~% 1106685-61-3

文献：Reddy, Manne Satyanarayana; Nagaraju, Chakilam; Ramprasad, Achampeta Kodanda Patent: US2011/263854 A1, 2011 ; US 20110263854 A1

119-61-9 ~% 1106685-61-3

文献：Reddy, Manne Satyanarayana; Nagaraju, Chakilam; Ramprasad, Achampeta Kodanda Patent: US2011/263854 A1, 2011 ; US 20110263854 A1

35144-22-0 ~% 1106685-61-3

文献：Peng, Xianyou; Li, Peijun; Shi, Yian Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 701 - 703

1431363-04-0 ~% 1106685-61-3

文献：CIPLA LIMITED; KING, Lawrence; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra Narayanrao; NAIK, Sanjay; GHAGARE, Maruti; CHIKHALIKAR, Sandip Vasant Patent: WO2013/57468 A1, 2013 ;

上下游产品

上游产品  6
35144-22-0 177036-78-1 178306-52-0 178306-47-3
178306-51-9 119-61-9
下游产品  0

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%