178306-52-0

• 常用中文名：(S)-2-羟基-3-甲氧基-3,3-二苯基丙酸
• 常用英文名：2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
• CAS号：178306-52-0
• 分子式：C₁₆H₁₆O₄
• 分子量：272.296
• 发布时间：2019-01-29 18:18:40
• 更新时间：2026-07-07 11:33:14
• 安倍生坦中间体

名称

• 中文名: (S)-2-羟基-3-甲氧基-3,3-二苯基丙酸
• 英文名: (2S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid
• 中文别名: N-(3-吖丁啶基)哌啶二盐酸盐; 安立生坦杂质8; 安立生坦羟基酸杂质; 安倍生坦中间体; 安倍生坦杂质5; 安立生坦中间体; 安倍生坦1; 安倍生坦杂质7; (S)-2-羟基-3-甲氧基-3,3-二苯基丙酸(安倍生坦中间体); S-2-羟基-3-甲氧基-3,3-二苯基丙酸 ALST-3; 安立生坦杂质; (S)-2-羟基l-3-甲氧基-3,3-二苯基丙酸; 安倍生坦羟基酸杂质; S-2-羟基-3-甲氧基-3; 安贝生坦羟基杂质; 安立生坦相关杂质
• 英文别名: (S)-2-Hydroxyl -3-Methoxy-3,3-diphenylpropanoic acid; 3-diphenylpropanoic acid; AMbrisentan InterMediate; Ambrisentan Hydroxy Acid Impurity (S-Isomer); (2S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid; benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,(aS); "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid"Q: What is "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What is the CAS Number of "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What is the storage condition of "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid" Q: What e the applications of "(S)-2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid"; (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid; benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, (αS); (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid; ALST-3; Ambrisentan Hydroxy Acid Impurity; S-2-Hydroxy-3-methoxy-3; fd7216; Ambrisentan Hydroxy Impurity; Ambrisentan Related compound A

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 430.3±45.0 °C at 760 mmHg
• 熔点: 120 °C(dec.)
• 分子式: C₁₆H₁₆O₄
• 分子量: 272.296
• 闪点: 158.4±22.2 °C
• 精确质量: 272.104858
• PSA: 66.76000
• LogP: 4.10
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.592
• 储存条件: 室温

合成路线

178306-51-9 ~53% 178306-52-0

文献：NATCO PHARMA LIMITED; KOMPELLA, Amala; ADIBHATLA, Kali Satya Bhujanga Rao; BALINA, Veera Swamy; KASA, Srinivasu; NANNAPANENI, Venkaiah Chowdary Patent: WO2012/17441 A1, 2012 ; Location in patent: Page/Page column 11-12 ;

119-61-9 ~% 178306-52-0

文献：US2011/263854 A1, ; US 20110263854 A1

178306-47-3 ~% 178306-52-0

文献：US2011/263854 A1, ; US 20110263854 A1

76527-25-8 ~% 178306-52-0

文献：WO2012/17441 A1, ;

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