406-76-8

• 常用中文名：DL-肉碱
• 常用英文名：DL-Carnitine
• CAS号：406-76-8
• 分子式：C₇H₁₅NO₃
• 分子量：161.199
• 相关类别： 研究领域 其他
• 发布时间：2018-09-10 17:28:18
• 更新时间：2024-01-03 12:23:36
• DL-Carnitine是L-Carnitine 和 D-Carnitine的外消旋混合物,调节线粒体脂肪酸转运, 提升血清肉碱组分。

名称

• 中文名: DL-肉碱
• 英文名: carnitinium
• 英文别名: L-(-)-Carnitine; (-)-L-Carnitin; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium Hydroxide Inner Salt; L(-)-Carnitine; (R)-Carnitine; Carnitine, L-; 3-Hydroxy-4-trimethylammoniobutanoate; UNII:S7UI8SM58A; (L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide inner salt; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L-; Carnitine DL-form; L-Carnitine; BICARNESINE; 3-Hydroxy-4-(trimethylammonio)butanoate; Cardiogen; g-Trimethylammonium-b-hydroxybutirate; 4-Copab; Monocamin; L-Carnitine inner salt; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt; g-Trimethyl-b-hydroxybutyrobetaine; (-)-Carnitine; (3R)-3-Hydroxy-4-(trimethylammonio)butanoate; DL-Carnitine; (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate; carnitine (L-form); Levocarnitine; g-Amino-b-hydroxybutyric Acid Trimethylbetaine; (R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide inner salt; (−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate; γ-Trimethyl-β-hydroxybutyrobetaine; Carnitine, (-)-; D,L-carnitine; (±)-carnitine; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-; carnitine

物化性质

• 分子式: C₇H₁₅NO₃
• 分子量: 161.199
• 精确质量: 161.105194
• PSA: 60.36000
• LogP: -4.52
• 储存条件: 2-8℃

生物活性

• 描述: DL-Carnitine是L-Carnitine 和 D-Carnitine的外消旋混合物,调节线粒体脂肪酸转运, 提升血清肉碱组分。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BP2979900 CHEMICAL NAME : Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, DL- CAS REGISTRY NUMBER : 406-76-8 LAST UPDATED : 198912 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C7-H15-N-O3 MOLECULAR WEIGHT : 161.23 WISWESSER LINE NOTATION : QV1YQ1K1&1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 13500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 995 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2008578 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 11500 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Lungs, Thorax, or Respiration - cyanosis REFERENCE : ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 3,28,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 610 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2008578

安全

• 海关编码: 2923900090

合成路线

107-20-0 463-51-4 75-50-3 ~% 541-15-1 详细

文献：Hanselmann, Paul; Klegraf, Ellen; Elzner, Stephan; Quittmann, Wilhelm; Fischer, Daniel Friedrich Patent: US2012/22275 A1, 2012 ; Location in patent: Page/Page column 10 ;

99211-78-6 ~% 406-76-8

文献：Jain, Rajendra P; Williams, Robert M Tetrahedron, 2001 , vol. 57, # 30 p. 6505 - 6509

133039-09-5 ~80% 406-76-8

文献：Bellamy; Bondoux; Dodey Tetrahedron Letters, 1990 , vol. 31, # 50 p. 7323 - 7326

32224-01-4 ~% 406-76-8

文献：Fuganti, Claudio; Grasselli, Piero Tetrahedron Letters, 1985 , vol. 26, # 1 p. 101 - 104

7013-07-2 74-88-4 ~% 541-15-1 406-76-8

文献：Bose, D. Subhas; Fatima, Liyakat; Rajender, Salla Synthesis, 2006 , # 11 p. 1863 - 1867

461-06-3 ~% 541-15-1 406-76-8

文献：Berthod; Valleix; Tizon; Leonce; Caussignac; Armstrong Analytical Chemistry, 2001 , vol. 73, # 22 p. 5499 - 5508

461-06-3 ~% 406-76-8

文献：Mueller; Strack Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, 1972 , vol. 353, # 4 p. 618 - 622

5261-99-4 ~% 406-76-8

文献：Bernabei, Ida; Castagnani, Roberto; Angelis, Francesco De; Witt Scalfaro, Paolo De; Giannessi, Fabio; et al. Angewandte Chemie, 1994 , vol. 106, # 20 p. 2202 - 2203

上下游产品

上游产品  9
107-20-0 463-51-4 75-50-3 133039-09-5
32224-01-4 7013-07-2 74-88-4 461-06-3
5261-99-4
下游产品  1
5469-16-9

海关

海关编码	2923900090
中文概述	2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%