4510-16-1

• 常用中文名：9β,11α-前列腺素F2
• 常用英文名：Prostaglandin F2β
• CAS号：4510-16-1
• 分子式：C₂₀H₃₄O₅
• 分子量：354.48
• 相关类别： 研究领域 其他
• 发布时间：2018-05-26 08:00:00
• 更新时间：2026-07-13 13:41:22
• (5R)-地诺前列素是由花生四烯酸的环氧合酶代谢产生的代谢产物。(5R)-地诺前列素(前列腺素F2β)诱导含己糖粘蛋白的剂量依赖性释放[1][2]。

名称

• 中文名: 同分异构体(物),同质异能素
• 英文名: prostaglandin F2β
• 英文别名: isomer; Chloro-17-acetoxy Progesterone (contains ~ 6-β 9BETA, 11ALPHA-PROSTAGLANDIN F2; prostaglandin F2beta; (Z)-7-[(1R,2R,3R,5R)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]ht-5-enoic acid; pgf2-beta; 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-htenoicacistereo; pgf(sub2-beta); 9β-PGF2α; Indigo Cmine 5,7’ 9BETA,11ALPHA-PGF2; (5Z,9R,13E,15S)-9β,11α,15-Trihydroxyprosta-5,13-diene-1-oic acid; 5-Htenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl) -, stereoisomer; Prostaglandin F2β MaxSpec Standd; (5Z,9β,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid; 9,11a-Prostaglandin F2(PGF2); prostaglandinf(sub2-beta); Prostaglandin F2b; Sofosbuvir α Prostaglandin F2 MaxSpecStandd; prosta-5,13-dien-1-oicacid,9,11,15-trihydroxy-,(5z,9-beta,11-alpha,13e,15s; 9BETA-PGF2ALPHA; PROSTAGLANDIN F2BETA; PGF2β; 9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID; 9β,11α-Prostaglandin F2; JWH 307 3’ Prostaglandin F2β Lipid Maps MS Standd

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 531.0±50.0 °C at 760 mmHg
• 熔点: 105-106ºC
• 分子式: C₂₀H₃₄O₅
• 分子量: 354.48
• 闪点: 289.0±26.6 °C
• 精确质量: 354.240631
• PSA: 97.99000
• LogP: 2.14
• 外观性状: 白色固体
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.569

生物活性

• 描述: (5R)-地诺前列素是由花生四烯酸的环氧合酶代谢产生的代谢产物。(5R)-地诺前列素(前列腺素F2β)诱导含己糖粘蛋白的剂量依赖性释放[1][2]。
• 相关类别:
  研究领域 >> 其他
• 参考文献:

  [1]. Lamont JT, et, al. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Gastroenterology. 1983 Feb;84(2):306-13.

  [2]. Jang Y, et, al. Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation. 2020 Jan 22;17(1):30.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MJ9658000 CHEMICAL NAME : 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)- , stereoisomer CAS REGISTRY NUMBER : 4510-16-1 LAST UPDATED : 198910 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H34-O5 MOLECULAR WEIGHT : 354.54 WISWESSER LINE NOTATION : L5TJ AQ B2U4VQ C1U1YQ5 DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 10 mg/kg SEX/DURATION : female 19 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition REFERENCE : BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 36,188P,1969