78756-33-9

• 常用中文名：氟马西尼杂质F
• 常用英文名：Flumazenil Impurity F
• CAS号：78756-33-9
• 分子式：C₁₅H₁₄ClN₃O₃
• 分子量：319.74300
• 发布时间：2018-12-27 16:41:18
• 更新时间：2024-01-18 18:21:38

名称

• 中文名: 8-氯-5,6-二氢-5-甲基-6-氧代-4H-咪唑并[1,5-a][1,4]苯并二氮杂卓-3-羧酸乙酯
• 英文名: Ethyl 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]b enzodiazepine-3-carboxylate
• 中文别名: 氟马西尼杂质F
• 英文别名: Ethyl 8-chloro-1-ethyl-4-oxo-4H-quinolizine-3-carboxylate; ethyl 8-chloro-1-ethyl-4H-quinolizin-4-one-3-carboxylate; Flumazenil Impurity F

物化性质

• 密度: 1.43g/cm3
• 沸点: 554ºC at 760 mmHg
• 分子式: C₁₅H₁₄ClN₃O₃
• 分子量: 319.74300
• 闪点: 288.9ºC
• 精确质量: 319.07200
• PSA: 64.43000
• LogP: 2.22590
• 折射率: 1.658

合成路线

2999-46-4 ~46% 78756-33-9

文献：WiSys Technology Foundation, Inc. Patent: US2006/258643 A1, 2006 ; Location in patent: Page/Page column 31-32 ; US 20060258643 A1

2999-46-4 865-47-4 814-49-3 5973-29-5 ~% 详细

文献：Hoffman-La Roche Inc. Patent: US4316839 A1, 1982 ;

2999-46-4 1027918-09-7 ~% 78756-33-9

文献：Yang, Jie; Teng, Yun; Ara, Shamim; Rallapalli, Sundari; Cook, James M. Synthesis, 2009 , # 6 art. no. M05108SS, p. 1036 - 1040

5973-29-5 ~% 78756-33-9

文献：Gu, Zi-Qiang; Wong, Garry; Dominguez, Celia; Costa, Brian R. de; Rice, Kenner C.; Skolnick, Phil Journal of Medicinal Chemistry, 1993 , vol. 36, # 8 p. 1001 - 1006

2999-46-4 5973-29-5 ~% 78756-33-9

文献：Watjen, Frank; Baker, Raymond; Engelstoff, Mogens; Herbert, Richard; MacLeod, Angus; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2282 - 2291

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