3590-93-0

• 常用中文名：4 ’-去甲去氧鬼臼毒素
• 常用英文名：4-Demethyldeoxypodophyllotoxin
• CAS号：3590-93-0
• 分子式：C₂₁H₂₀O₇
• 分子量：384.37900
• 相关类别： 研究领域 其他
• 发布时间：2018-03-04 08:00:00
• 更新时间：2026-07-16 11:21:36
• 4-去甲基脱氧鬼臼毒素是一种芳基木脂素,可在鬼臼中找到[1]。

名称

• 中文名: 4 ’-去甲去氧鬼臼毒素
• 英文名: (5R,5aR,8aR)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one
• 中文别名: 依托泊苷杂质19(4′-去甲基脱氧鬼臼毒素); 4 '-去甲去氧鬼臼毒素; 鬼臼毒素杂质4
• 英文别名: Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5,8); 4'-Demethyl-4-deoxypodophyllotoxin; 4'-demethyl; (5R,5,8-5-(4-hydroxy-3,5-dimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-benzofuro[5,6-f][1,3]benzodioxol-6-one; (5R,5aα,8aβ)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; 4’－Demethyldeoxypodophyllotoxin; Etoposide Impurity 19(4′-Demethyldeoxypodophyllotoxin); (5R)-5,5aα,6,8,8aβ,9-Hexahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-one; 4'-Demethyldesoxypodophyllotoxin; (5R,5aα)-5,8,8aβ,9-Tetrahydro-5β-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; 4′-Demethyldesoxypodophyllotoxin; 7-Dehydroxy-4-demethylpodophyllotoxin; 4-demethyl-deoxypodophyllotoxin; Podophyllotoxin p-Desmethyl 9-Desoxy Impurity

物化性质

• 分子式: C₂₁H₂₀O₇
• 分子量: 384.37900
• 精确质量: 384.12100
• PSA: 83.45000
• LogP: 2.61530

生物活性

• 描述: 4-去甲基脱氧鬼臼毒素是一种芳基木脂素,可在鬼臼中找到[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry. 1984, 23 (5): 1147-1152.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LV2476000 CAS REGISTRY NUMBER : 3590-93-0 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C21-H20-O7 MOLECULAR WEIGHT : 384.41 WISWESSER LINE NOTATION : T E5 C665 FVO NO PO OHTT&TJ DR DQ CO1 EO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Human HeLa cell DOSE/DURATION : 100 umol/L REFERENCE : BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 15,5443,1976

合成路线

6559-91-7 ~73% 3590-93-0

文献：Chen, Shi-Wu; Gao, Yuan-Yu; Zhou, Ni-Ni; Liu, Jie; Huang, Wen-Ting; Hui, Ling; Jin, Yan; Jin, Yong-Xin Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7355 - 7358

477-51-0 ~87% 3590-93-0

文献：Terada; Fujimoto; Nomura; Yamashita; Kobunai; Takeda; Wierzba; Yamada; Yamaguchi Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 10 p. 2720 - 2727

40505-27-9 ~% 3590-93-0

文献：Jackson, David E.; Dewick, Paul M. Phytochemistry (Elsevier), 1984 , vol. 23, # 5 p. 1147 - 1152

518-28-5 ~% 3590-93-0

文献：Chen, Shi-Wu; Gao, Yuan-Yu; Zhou, Ni-Ni; Liu, Jie; Huang, Wen-Ting; Hui, Ling; Jin, Yan; Jin, Yong-Xin Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 24 p. 7355 - 7358

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