40505-27-9

• 常用中文名：4'-去甲鬼臼毒素
• 常用英文名：4'-demethylpodophyllotoxin
• CAS号：40505-27-9
• 分子式：C₂₁H₂₀O₈
• 分子量：400.37900
• 相关类别： 研究领域 癌症
• 发布时间：2018-02-19 08:00:00
• 更新时间：2026-07-01 12:57:12
• 4'-Demethylpodophyllotoxin 是 Podophyllum hexandrum 根和 P. peltatum 中含有的一种木脂素类化合物。4'-Demethylpodophyllotoxin 对多种癌细胞系具有潜在的细胞毒性。

名称

• 中文名: 4'-去甲鬼臼毒素
• 英文名: 4'-demethylpodophyllotoxin
• 中文别名: 4'-去甲基鬼臼毒素,10 MM DMSO 溶液; 4'-Demethylpodophyllotoxin 4'-去甲鬼臼毒素，S; (5R,5,8,9R)-9-羟基-5-(4-羟基-3,5-二甲氧基苯基)-5,5A,8A,9-四氢呋喃并[3',4':6,7]萘[ 2,3-D] [1,3]二氧杂环戊烯-6-(8H)-酮; 4'-Demethylpodophyllotoxin 4'-去甲鬼臼毒素,S; 鬼臼毒素杂质1; 依托泊苷杂质L; 依托泊甙杂质L; 4`-去甲氧基鬼臼毒素; 4'-去甲基鬼臼毒素对照品; 依托泊苷杂质12(依托泊苷杂质L); 4'-去甲基鬼臼毒素; 4'-脱甲基足叶毒素
• 英文别名: (5R,5,8,9R)-9-Hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one; Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5,8,9R); 4'-O-demethylpodophyllotoxin; 4'-Demethylpodophyllotoxin; 9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one; (5R)-9β-Hydroxy-5,8,8aβ,9-tetrahydro-5β-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one; Etoposide Impurity 12 (Etoposide Impurity L); (5R)-5,8,8aβ,9-Tetrahydro-9β-hydroxy-5β-(3,5-dimethoxy-4-hydroxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aαH)-one; 4-demethylepipodophyllotoxin; 4-demethylpodophylloto; (5R,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one; 4''-Demethylpodophyllotoxin; 4''-Demethylpodophyllotoxin, 10 mM in DMSO; 4'-Demethylpodophyllotoxin //BP; (5R)-5β-(4-Hydroxy-3,5-dimethoxyphenyl)-9β-hydroxy-5,5aα,6,8,8aβ,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6-one; (5R)-5,8,8aβ,9-Tetrahydro-5β-(3,5-dimethoxy-4-hydroxyphenyl)-9β-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(5aαH)-one; 5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one; Etoposide Impurity L (4’-Demethylpodophyllotoxin)

物化性质

• 密度: 1.446 g/cm3
• 沸点: 626.5ºC at 760 mmHg
• 分子式: C₂₁H₂₀O₈
• 分子量: 400.37900
• 闪点: 224.4ºC
• 精确质量: 400.11600
• PSA: 103.68000
• LogP: 2.10620
• 外观性状: 粉末
• 折射率: 1.637
• 储存条件: -20℃

生物活性

• 描述: 4'-Demethylpodophyllotoxin 是 Podophyllum hexandrum 根和 P. peltatum 中含有的一种木脂素类化合物。4'-Demethylpodophyllotoxin 对多种癌细胞系具有潜在的细胞毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23(5): 1147-1152.

  [2]. Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LV2476100 CAS REGISTRY NUMBER : 40505-27-9 BEILSTEIN REFERENCE NO. : 0099005 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C21-H20-O8 MOLECULAR WEIGHT : 400.41 WISWESSER LINE NOTATION : T E5 C665 FVO NO PO OHTT&&J DR DQ CO1 EO1& JQ HEALTH HAZARD DATA ACUTE TOXICITY DATA MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human HeLa cell DOSE/DURATION : 40 umol/L REFERENCE : BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 15,5443,1976

合成路线

518-28-5 ~% 40505-27-9

文献：Sk, Ugir Hossain; Dixit, Deobrat; Sen, Ellora European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 47 - 57

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