77-51-0

• 常用中文名：异米尼克
• 常用英文名：isoaminile
• CAS号：77-51-0
• 分子式：C₁₆H₂₄N₂
• 分子量：244.37500
• 相关类别： 原料药 呼吸系统用药 镇咳药
• 发布时间：2018-06-23 17:07:40
• 更新时间：2024-04-05 11:26:10

名称

• 中文名: 异米尼克
• 英文名: 4-(dimethylamino)-2-phenyl-2-propan-2-ylpentanenitrile
• 英文别名: Nullatuss; 4-(Dimethylamino)-2-isopropyl-2-phenylvaleronitrile; Isoaminile; Isoaminilo [INN-Spanish]; EINECS 201-033-5; Isoaminil; Isoaminilum [INN-Latin]; Aprecon

物化性质

• 密度: 0.952g/cm3
• 沸点: 346.1ºC at 760mmHg
• 分子式: C₁₆H₂₄N₂
• 分子量: 244.37500
• 闪点: 136.2ºC
• 精确质量: 244.19400
• PSA: 27.03000
• LogP: 3.44418
• 折射率: 1.504
• 储存条件: -196°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YV8520000 CHEMICAL NAME : Valeronitrile, 4-(dimethylamino)-2-isopropyl-2-phenyl- CAS REGISTRY NUMBER : 77-51-0 LAST UPDATED : 199707 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C16-H24-N2 MOLECULAR WEIGHT : 244.42 WISWESSER LINE NOTATION : 1Y1&XR&CN&1Y1&N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 378 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,323,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,323,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 127 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,323,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,323,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 48400 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,323,1968