381212-03-9

• 常用中文名：Pefcalcitol
• 常用英文名：Pefcalcitol
• CAS号：381212-03-9
• 分子式：C₂₆H₃₄F₅NO₄
• 分子量：519.544
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2017-09-19 15:48:49
• 更新时间：2025-08-24 23:14:38
• Pefcalcitol是一种具有16-en-22-oxa-维生素D3结构的新型抗溃疡药物候选药物。

名称

• 英文名: 2-[(1S)-1-[(3aS,4E,7aS)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-1-yl]ethoxy]-N-(2,2,3,3,3-pentafluoropropyl)acetamide
• 英文别名: 2-{[(1S,3R,5Z,7E,9ξ,20S)-1,3-Dihydroxy-9,10-secopregna-5,7,10,16-tetraen-20-yl]oxy}-N-(2,2,3,3,3-pentafluoropropyl)acetamide; M5181; Pefcalcitol; 2-(((1S,3R,5z,7E,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(19),16-tetraen-20-yl)oxy)-N-(2,2,3,3,3-pentafluoropropyl)acetamide; UNII-KT5224XSHW; Acetamide,2-((1S)-1-((3aS,7E,7as)-7-((2Z)-((3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene)ethylidene)-3a,4,5,6,7,7a-hexahydro-3a-methyl-1H-inden-3-yl)ethoxy)-N-(2,2,3,3,3-pentafluoropropyl); Acetamide, 2-[(1S)-1-[(3aS,7E,7aS)-7-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]-3a,4,5,6,7,7a-hexahydro-3a-methyl-1H-inden-3-yl]ethoxy]-N-(2,2,3,3,3-pentafluoropropyl)-; Pefcalcitol [INN]

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 614.0±55.0 °C at 760 mmHg
• 分子式: C₂₆H₃₄F₅NO₄
• 分子量: 519.544
• 闪点: 325.1±31.5 °C
• 精确质量: 519.240784
• PSA: 82.28000
• LogP: 5.42
• 蒸汽压: 0.0±4.0 mmHg at 25°C
• 折射率: 1.523

生物活性

• 描述: Pefcalcitol是一种具有16-en-22-oxa-维生素D3结构的新型抗溃疡药物候选药物。
• 相关类别:
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Akira Takeiri, Kenji Tanaka. et al. Lack of Mutagenicity of SMD-502, a New Vitamin D3 Analog for Topical Application, in Skin and Liver of gpt delta Transgenic Mice and in GDL1 Cells. Genes and Encironment, Vol, 34, No. 3 pp. 107-114(2012)