55-31-2

• 常用中文名：盐酸肾上腺素
• 常用英文名：L-Epinephrine hydrochloride
• CAS号：55-31-2
• 分子式：C₉H₁₄ClNO₃
• 分子量：219.665
• 相关类别： 原料药 循环系统用药 抗休克血管活性药
• 发布时间：2018-07-24 09:06:54
• 更新时间：2024-01-02 08:53:47
• L-Epinephrine hydrochloride ((-)-Epinephrine hydrochloride; L-Adrenaline hydrochloride; (-)-Adrenalin hydrochloride) 是一种内源性神经递质激素 neurotransmitter hormone,用于治疗过敏和呼吸系统疾病。
• 激动心肌、传导系统和窦房结的β受体，使心肌收缩
  盐酸肾上腺素
  盐酸肾上腺素
  力增强，心输出量增加，传导加速和心率增快。激活皮肤粘膜和内脏血管的β2受体，尤其是肾动脉明显收缩，骨骼肌和冠状动脉则扩张。激动支气管β2受体，使支气管扩张。作用于肝和脂肪β2受体，促进肝糖原和脂肪分解，升高血糖。

名称

• 中文名: 盐酸肾上腺素
• 英文名: (R)-adrenaline hydrochloride
• 中文别名: (R)-4-[2-(甲氨基)-1-羟基乙基]-1,2-苯二酚盐酸盐; 卡非佐米; 肾上腺素盐酸
• 英文别名: [3H]-(+/-)-Epinephrine hydrochloride; DL-EPINEPHRINE HYDROCHLORIDE; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol hydrochloride; rs-epinephrine hcl; Racepinephrine/Adrenaline HCL; (+/-)-EPINEPHRINE HYDROCHLORIDE; (+/-)-adrenaline hydrochloride; L-Epinephrine hydrochloride; (-)-3,4-DIHYDROXY-α-((METHYLAMINO)METHYL)BENZYL ALCOHOL HYDROCHLORIDE; (+/-)-ADRENALIN HYDROCHLORIDE; 4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol hydrochloride (1:1); epinephrine HCl; RAC EPINEPHRINE HCL; (R/S)-adrenaline hydrochloride; Benzyl alcohol, 3,4-dihydroxy-α-((methylamino)methyl)-, hydrochloride, (-)-; l-1-(3,4-dihydroxyphenyl)-2-methylamino-1-ethanol hydrochloride; 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, hydrochloride (1:1); EINECS 200-230-3; UNII:336096P2WE; MFCD00801067; 4-[1-Hydroxy-2-(methylamino)ethyl]benzene-1,2-diol hydrochloride (1:1)

物化性质

• 沸点: 413.1ºC at 760 mmHg
• 熔点: 157°C
• 分子式: C₉H₁₄ClNO₃
• 分子量: 219.665
• 闪点: 207.9ºC
• 精确质量: 219.066223
• PSA: 72.72000
• LogP: 1.54350
• 外观性状: 晶体
• 储存条件:

  库房通风低温干燥; 与食品原料分开存放。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:5

  3.氢键受体数量:4

  4.可旋转化学键数量:3

  5.互变异构体数量:10

  6.拓扑分子极性表面积72.7

  7.重原子数量:14

  8.表面电荷:0

  9.复杂度:154

  10.同位素原子数量:0

  11.确定原子立构中心数量:1

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1.熔点（157ºC）：157

生物活性

• 描述: L-Epinephrine hydrochloride ((-)-Epinephrine hydrochloride; L-Adrenaline hydrochloride; (-)-Adrenalin hydrochloride) 是一种内源性神经递质激素 neurotransmitter hormone,用于治疗过敏和呼吸系统疾病。
• 相关类别:
  研究领域 >> 神经疾病
• 靶点:

  IC50: Endogenous neurotransmitter hormone[1]

• 参考文献:

  [1]. Zwicker P, et al.A proteomic approach for the identification of immunotoxic properties of Tulipalin A.Proteomics. 2016 Dec;16(23):2997-3008.

  [2]. McCluskey J, et al. Tulipalin A induced phytotoxicity.Int J Crit Illn Inj Sci. 2014 Apr;4(2):181-3.

  [3]. National Toxicology Program, et al.NTP Toxicology and Carcinogenesis Studies of l-Epinephrine Hydrochloride (CAS No. 55-31-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Natl Toxicol Program Tech Rep Ser. 1990 Mar;380:1-205.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DO3150000 CHEMICAL NAME : Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (-)- CAS REGISTRY NUMBER : 55-31-2 LAST UPDATED : 199712 DATA ITEMS CITED : 22 MOLECULAR FORMULA : C9-H13-N-O3.Cl-H MOLECULAR WEIGHT : 219.69 WISWESSER LINE NOTATION : QR BQ DYQ1M1 &GH -L HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,101,1925 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraduodenal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 180,155,1969 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,51,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4664 ug/kg TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,110,1947 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1980 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,214,1946 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 9,289,1970 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,51,1963 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,51,1963 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12500 ug/m3/6H/14D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-380,1990 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/m3/6H/13W-I TOXIC EFFECTS : Cardiac - changes in heart weight Endocrine - changes in adrenal weight Related to Chronic Data - death REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-380,1990 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/m3/6H/1.3Y-I TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-380,1990 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 50 mg/m3/6H/14D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-380,1990 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/m3/6H/13W-I TOXIC EFFECTS : Gastrointestinal - other changes Liver - changes in liver weight Related to Chronic Data - death REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-380,1990 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3 mg/m3/6H/1.3Y-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-380,1990 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 125 ug/kg SEX/DURATION : female 17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) REFERENCE : BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 43,270,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3200 ug/kg SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - stillbirth REFERENCE : CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 43,473,1965 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 7950 ng/kg SEX/DURATION : female 22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 153,373,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4602 No. of Facilities: 37 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 372 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4602 No. of Facilities: 284 (estimated) No. of Industries: 1 No. of Occupations: 12 No. of Employees: 7694 (estimated) No. of Female Employees: 6481 (estimated)

安全

• 风险声明 (欧洲): 24/25-36/37/38
• 安全声明 (欧洲): 26-36/37-45
• 危险品运输编码: 3249
• 包装等级: II
• 危险类别: 6.1(a)