52980-28-6

• 常用中文名：1,4-二氢-4-氧代-3-喹啉羧酸乙酯
• 常用英文名：Ethyl 4-hydroxy-3-quinolinecarboxylate
• CAS号：52980-28-6
• 分子式：C₁₂H₁₁NO₃
• 分子量：217.221
• 发布时间：2018-12-24 11:07:52
• 更新时间：2024-01-02 22:38:48

名称

• 中文名: 1,4-二氢-4-氧代-3-喹啉羧酸乙酯
• 英文名: 4-hydroxy-quinoline-3-carboxylic acid methyl ester
• 英文别名: ethyl 1,4-dihydro-4-oxo-3-quinolinecarboxylate; Methyl 4-hydroxyquinoline-3-carboxylate; ethyl 1,4-dihydro-4-oxoquinoline-3-carboxylate; T66 BM EVJ DVO2; 3-Ethoxycarbonyl-4-hydroxyquinoline; 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Ethyl Ester; 3-Ethoxycarbonyl-4-quinolone; Ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate; 4-Hydroxy-3-ethoxycarbonylquinoline; Ethyl 4-hydroxy-3-quinolinecarboxylate; quinolin-4(1H)-one-3-carboxylic acid ethyl ester; 3-(Carboethoxy)-4-quinoline; 4-Oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester; T66 BNJ DVO2 EQ; ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate (en); 4-Hydroxyquinoline-3-carboxylic acid ethyl ester; Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate; quinolin-4(1H)-on-3-carboxylic acid ethyl ester; 1,4-dihydro-oxoquinoline-3-carboxylic acid ethyl ester; 3-Quinolinecarboxylic acid, 4-hydroxy-, ethyl ester; IFLAB-BB F0777-1766

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 334.9±22.0 °C at 760 mmHg
• 熔点: 270ºC
• 分子式: C₁₂H₁₁NO₃
• 分子量: 217.221
• 闪点: 156.4±22.3 °C
• 精确质量: 217.073898
• PSA: 59.16000
• LogP: 3.88
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.632
• 储存条件: 室温，干燥

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate CAS number:52980-28-6 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C12H11NO3 Molecular weight: 217.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2933499090

合成路线

74497-02-2 87-13-8 ~% 52980-28-6

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 23 p. 2661 - 2664

54535-22-7 ~84% 52980-28-6

文献：Cao, Xin; You, Qi-Dong; Li, Zhi-Yu; Yang, Yan; Wang, Xiao-Jian Synthetic Communications, 2009 , vol. 39, # 24 p. 4375 - 4383

261629-95-2 ~70% 52980-28-6

文献：Kim, Jae Nyoung; Lee, Ka Young; Kim, Hyoung Shik; Kim, Tae Yi Organic Letters, 2000 , vol. 2, # 3 p. 343 - 345

1260522-59-5 ~76% 52980-28-6

文献：Bunce, Richard A.; Nammalwar, Baskar Organic Preparations and Procedures International, 2010 , vol. 42, # 6 p. 557 - 563

74497-02-2 ~% 52980-28-6

文献：European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452

87-13-8 ~% 52980-28-6

文献：European Journal of Medicinal Chemistry, , vol. 46, # 4 p. 1448 - 1452

552-89-6 ~% 52980-28-6

文献：Organic Letters, , vol. 2, # 3 p. 343 - 345

140-88-5 ~% 52980-28-6

文献：Organic Letters, , vol. 2, # 3 p. 343 - 345

198902-99-7 ~% 52980-28-6

文献：Organic Letters, , vol. 2, # 3 p. 343 - 345

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%