207557-35-5

• 常用中文名：(2S)-N-氯乙酰基-2-氰基四氢吡咯
• 常用英文名：(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
• CAS号：207557-35-5
• 分子式：C₇H₉ClN₂O
• 分子量：172.612
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-26 08:06:26
• 更新时间：2026-07-02 17:44:39

名称

• 中文名: (2S)-N-氯乙酰基-2-氰基四氢吡咯
• 英文名: (2S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile
• 中文别名: 维他列汀中间体; 维格列汀-01; (S) -1-(2-氯乙酰基)吡咯烷-2-碳腈; (2S)-N-氯乙酰基-2-氰基四氢吡咯(维达列汀); 维格列汀杂质II; 维格列汀氯乙酰丁腈(S)-异构体; (S)-1-(2-氯乙酰基)吡咯烷-2-甲腈; (S)-1-(氯乙酰基)-2-氰基吡咯烷,维达列汀中间体; (S)-1-(2-氯乙基)-2-氰基吡咯烷; (2S)-N-氯乙酰基-2-氰基四氢吡咯(维达列汀中间体); (2S)-N-氯乙酰基-2-氰基四氢; 维达列汀中间体; 维达列汀杂质56; 维格列汀杂质14对照品; 维达列汀杂质K; 维格列汀中间体C; VILDAGLIPTIN中间体; S-1-氯乙酰基-2-氰基吡咯烷; 维格列汀杂质J; 阿拉格列汀A3; 化合物 (S)-1-(2-CHLOROACETYL)PYRROLIDINE-2-CBONITRILE; 维格列汀中间体,(2S)-N-氯乙酰基-2-氰基四氢吡咯; 2S-1-(2-氯乙酰基)吡咯烷-2-甲腈; 阿拉格列汀-VIGA3; (2S)-1-(氯乙酰基)-2-氰基吡咯烷; 维格列汀-IM A 维格列汀-IM A3 维格列汀-01; (2S)-N-氯乙酰基-2-氧基四氢吡咯; 维格列汀WG103对照品; (2S)-1-氯乙酰基-2-氰基吡咯; (2S)-N-氯乙酰基-2-氰基吡咯烷; 阿拉格列汀 INT B3; 氯乙酰基-2-氰基四氢吡咯; 维达列汀杂质 15; (2|S|)-N-氯乙酰基-2-氰基四氢吡咯; (2S)-N-氯乙酰基-2-吡咯烷甲腈; S)-1-(2-氯乙酰基)-2-氰基吡咯; 维达列汀中间体2
• 英文别名: 2-pyrrolidinecbonitrile; C7HIN2O; (S)-1-(2-Chloroacetyl)pyrrolidine-carbonitrile; 1-CHLOROACETYL-2-(S)-CYANOPYRROLIDINE; (S)-1-(2-Chloroacetyl)-2-cyanopyrrolidine; (S)-1-(2-CHLORO ACETYL) PYRROLIDINE-2- CBONITRIL; (2S)-1-(2-Chloroacetyl)-pyrrolidinecbonitrile; vildagliptin Impurity J; 1-(2-Chloroacetyl)-pyrrolidine-(2S)-carbonitrile; (2S)-N-Chloroacetyl-2-cyanotetrahydrofuran; (S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile(S)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile; (2S)-1-(CHLOROACETYL)-2-PYRROLIDINECBONITRILE; 1-(2-chloroacetyl)pyrrolidine-2-carbonitrile; Vildagliptin interMediates; (S)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile (CA; (2S) -N-chloroacetyl-2-cyano-tetrahydropyrrole; (2S)-1-chloroacetyl-2-pyrrolidine carbonitrile CAS No; (2S)1-(CHLOROACETYL)-2-PYRROLIDINE CARBONITRILE; Vildagliptin Impurity，(2S)-1-(Chloroacetyl)-2- pyrrolidinecbonitrile; (2S)-1-(Chloroacetyl)-2-pyrrolidinecbonitrile ISO 9001：2015 REACH; Vildagliptin Chloroacetyl Nitrile Impurity; Vildagliptin Chloroacetyl Nitrile (S)-Isomer (2S)-1-(Chloroacetyl)-2-Pyrrolidinecbonitrile; 2-Pyrrolidinecbonitrile, 1-(2-chloroacetyl)-, (2S); Vildagliptin Intermediate 2; Vildagliptin interMediate C; cas:207-5; Vigliptin Impurity 14; Tetrahydropyrole; 2S-1-(2-Chloroacetyl)-pyrrolidinec; 2S)-N-(Chloroacetyl)-2-Pyrrolidine carbonitrile; (S)-2-cyanopyrrolidine-1-carbonyl chloride; (2S)-1-CHLOROACETYLPYRROLIDINE-2-carbonitrile; Purity Reliable Suppier/Best price/In stock (2S)-1-(Chloroacetyl)-2-pyrrolidinecbonitrile; (S)-1-(Chloroacetyl)-2-pyrrolidinecbonitrile; (2S)-1-(CHLOROACETYL)-2-PYRROLIDINE-2-carbonitrile; (S)-1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile; (R)-hexahydroindolizin-7(1H)-one; (2S)-N-Chloroacetyl-2-cyanopyrrolidine; (S)-1-(2-CHLOROACETYL)PYRROLIDINE-2-carbonitrile; (S)-2-cyanopyrrolidine-1-carbonyl chlo; (2S)-1-(Chloroacetyl)-2-pyrrolidinecbonitrile (Vildagliptin); Vildagliptin Impurity 16/Vildagliptin Chloroacetyl Nitrile (S)-Isomer/(2S)-1-(Chloroacetyl)-2-Pyrrolidinecbonitrile; (2S)-N- chloroacetyl -2- cyanopyrrole; 1-chloroacetyl-2-(S)-pyrrolidinecarbonitrile; (S)-1-(2-Chloroacetyl)-2-pyrrolidine-2-carbonitrile; Vogliptin impurity II; Vildagliptin Chloroacetyl Nitrile (S)-Isomer; (S)-1-(2-Chloro-acetyl)-pyrrolidine-2-carbonitrile (2-C); (2S)-1-(Chloroacetyl)-2-pyrrolidinecbonitrile (2S)-1-(2-Chloroacetyl)-pyrrolidinecbonitrile; (2S)-1-(2-chloroacetyl)-2-Pyrrolidinecbonitrile; 2-Pyrrolidinecbonitrile, 1-(chloroacetyl)-, (2S)- (9CI); 2-Pyrrolidinecbonitrile, 1-(chloroacetyl)-, (2S); (S)-1-(Chloroacetyl)-2-cyanopyrrolidine; (2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile; 7(2S)-1-(Chloroacetyl)-2-pyrrolidinecbonitrile; (2S)-1-(chloroacetyl)-2-cyanopyrrolidine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 363.1±37.0 °C at 760 mmHg
• 熔点: 64 °C
• 分子式: C₇H₉ClN₂O
• 分子量: 172.612
• 闪点: 173.4±26.5 °C
• 精确质量: 172.040344
• PSA: 44.10000
• LogP: -0.62
• 外观性状: 固体;White to Light yellow to Light orange powder to crystal
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.519
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

安全

• 海关编码: 2942000000

合成路线

79-04-9 7531-52-4 ~66% 207557-35-5

文献：Medichem, S.A. Patent: US2008/167479 A1, 2008 ; Location in patent: Page/Page column 5 ;

214398-99-9 ~88% 207557-35-5

文献：Peng, Jun; Feng, Yue; Tao, Zhu; Chen, Yingjie; Hu, Xiangnan Letters in Organic Chemistry, 2013 , vol. 10, # 3 p. 159 - 163

204387-53-1 79-04-9 ~% 207557-35-5

文献：ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; PILLAI, Bijukumar Gopinathan; KEVAT, Jitendra; DUBADIA, Bhagwati; KAUSHAL, Anupriya Patent: WO2014/20462 A1, 2014 ; Location in patent: Page/Page column 9 ;

7531-52-4 ~% 207557-35-5

文献：Journal of Medicinal Chemistry, , vol. 46, # 13 p. 2774 - 2789

147-85-3 ~% 207557-35-5

文献：WO2006/90244 A1, ; Page/Page column 28 ; WO 2006/090244 A1

23500-10-9 ~% 207557-35-5

文献：WO2011/101861 A1, ;

2577-48-2 ~% 207557-35-5

文献：Letters in Organic Chemistry, , vol. 10, # 3 p. 159 - 163

35150-07-3 ~% 207557-35-5

文献：WO2014/20462 A1, ;

228244-04-0 ~% 207557-35-5

文献：WO2014/20462 A1, ;

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%