23500-10-9

• 常用中文名：1-(2-氯乙酰基)脯氨酸
• 常用英文名：1-(Chloroacetyl)-L-proline
• CAS号：23500-10-9
• 分子式：C₇H₁₀ClNO₃
• 分子量：191.612
• 发布时间：2018-08-30 14:49:20
• 更新时间：2026-07-16 10:29:51

名称

• 中文名: 1-(2-氯乙酰基)脯氨酸
• 英文名: 1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid
• 中文别名: 维格列汀-03; 1-(氯乙酰基)脯氨酸; 阿拉格列汀-VIGA1; (S)-1-(2-氯乙酰基)-2-羧基吡咯(维格列汀杂质12); (2S)-1-(2-氯乙酰基)脯氨酸; 维格列汀杂质 12; (S)-1-(2-氯乙酰基)吡咯烷-2-羧酸(维格列汀杂质); 维格列汀杂质P; (S)-1-(2-氯乙酰基)-2-吡咯甲酸; 1-(2-氯乙酰基)-L-脯氨酸; (S)-1-(2-氯乙酰基)-2-羧基吡咯; 维格列汀SQBL-3; 维格列汀杂质18对照品; 维格列汀-IM C 维格列汀-IM A1 维格列汀-03; (S)-1-(2-氯乙酰基)吡咯烷-2-羧酸; (2S)-1-(2-氯乙烷酰)吡咯烷-2-羧酸; 阿拉格列汀 IM A; 维达列汀杂质12; 阿拉格列汀 INT B1; (2S)-1-(2-氯-1-氧代乙基)-2-吡咯烷羧酸; (2S)-1-(2-氯乙酰基)吡咯烷-2-羧酸; 维达列汀杂质 18
• 英文别名: CLAC-PRO-OH; (S)-1-(2-Chloro-acetyl)-pyrrolidine-2-cboxylic acid; (2S)-N-Chloroacetylproline; (2S)-1-(2-chloroethanoyl)pyrrolidine-2-cboxylic acid; （S）-1-(2-CHLOROACETYL)PYRRPLIDINE-2-CBOXYLIC ACID; (S)-1-(2-chloroacetyl)pyrrolidine-2-cboxylic acid (2S)-N-Chloroacetylproline; Vildagliptin Impurity 9/(S)-1-(2-Chloro-acetyl)-pyrrolidine-2-cboxylic acid; 1-(chloroacetyl)proline; vildagliptin Impurity P; 1-chloroacetyl-L-proline; (S)-1-(2-Chloro-acetyl)-pyrrolidine-2-cboxylicacid; (2S)-1-(2-chloroacetyl)proline; 1-(2-Chloroacetyl)-L-Proline; N-chloroacetyl-L-proline; (2S)-1-(2-chloro-1-oxoethyl)-2-pyrrolidinecboxylic acid; L-Proline, 1-(2-chloroacetyl); Anagliptin Impurity 1; (S)-1-(2-Chloroacetyl)pyrrolidine-2-cboxylic; CHLOROACETYL-L-PROLINE; (2-chloroacetyl)-L-proline; (S)-1-(2-chloroacetyl)pyrrolidine-2-cboxylic acid (Vildagliptin Impurity）; Vildagliptin Impurity 12; Vildagliptin Impurity 36 P; Vildagliptin Impurity SQBL-3; (2S)-1-(2-chloroacetyl)pyrrolidine-2-cboxylic acid; CHLOROAC-PRO-OH; (Z)-2-((S)-2-cyanopyrrolidin-1-yl)-N-((1r,3R,5R,7S)-3-hydroxy adamantan-1-yl)-2-oxoethan-1-imine oxide

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 399.0±37.0 °C at 760 mmHg
• 分子式: C₇H₁₀ClNO₃
• 分子量: 191.612
• 闪点: 195.1±26.5 °C
• 精确质量: 191.034927
• PSA: 57.61000
• LogP: -0.46
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.539

安全

• 海关编码: 2933990090

合成路线

79-04-9 147-85-3 ~96% 23500-10-9

文献：Peng, Jun; Feng, Yue; Tao, Zhu; Chen, Yingjie; Hu, Xiangnan Letters in Organic Chemistry, 2013 , vol. 10, # 3 p. 159 - 163

79-11-8 147-85-3 ~% 23500-10-9

文献：Fedorov; Shestopalov; Belyakov Russian Chemical Bulletin, 2003 , vol. 52, # 10 p. 2197 - 2202

2812-47-7 ~% 23500-10-9

文献：Hamer; Greenstein Journal of Biological Chemistry, 1951 , vol. 193, p. 81,87

上下游产品

上游产品  4
79-04-9 147-85-3 79-11-8 2812-47-7
下游产品  4
214398-99-9 274901-16-5 207557-35-5 704-15-4

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%