263157-86-4

• 常用中文名：2-(2,6-二氯苄基)-1,3-噻唑-4-羰酰氯
• 常用英文名：2-(2,6-DICHLOROBENZYL)THIAZOLE-4-CARBONYL CHLORIDE
• CAS号：263157-86-4
• 分子式：C₁₁H₆Cl₃NOS
• 分子量：306.59500
• 发布时间：2018-12-24 13:01:13
• 更新时间：2024-01-10 10:28:02

名称

• 中文名: 2-(2,6-二氯苄基)-1,3-噻唑-4-羰酰氯
• 英文名: 2-[(2,6-dichlorophenyl)methyl]-1,3-thiazole-4-carbonyl chloride
• 英文别名: 2,6-DIMETHYL-4-MORPHOLINESULFONYL CHLORIDE; 2-(2,6-Dichlorobenzyl)-1,3-Thiazole-4-Carbonyl Chloride

物化性质

• 密度: 1.518g/cm3
• 沸点: 422ºC at 760 mmHg
• 熔点: 104ºC
• 分子式: C₁₁H₆Cl₃NOS
• 分子量: 306.59500
• 闪点: 209ºC
• 精确质量: 304.92400
• PSA: 58.20000
• LogP: 4.41970
• 蒸汽压: 2.5E-07mmHg at 25°C
• 折射率: 1.632

MSDS

Name: 2-(2 6-Dichlorobenzyl)-1 3-thiazole-4-carbonyl chloride 97% Material Safety Data Sheet Synonym: CAS: 263157-86-4 Section 1 - Chemical Product MSDS Name:2-(2 6-Dichlorobenzyl)-1 3-thiazole-4-carbonyl chloride 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 263157-86-4 2-(2,6-Dichlorobenzyl)-1,3-thiazole-4- 97% unlisted Hazard Symbols: C Risk Phrases: 34 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Causes burns.Moisture sensitive. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. Ingestion: Causes gastrointestinal tract burns. Inhalation: Causes chemical burns to the respiratory tract. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under an inert atmosphere. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 263157-86-4: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: off-white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 100 - 103 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C11H6Cl3NOS Molecular Weight: 307 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials, exposure to moist air or water. Incompatibilities with Other Materials: Bases, oxidizing agents, alcohols, amines. Hazardous Decomposition Products: Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 263157-86-4 unlisted. LD50/LC50: Not available. Carcinogenicity: 2-(2,6-Dichlorobenzyl)-1,3-thiazole-4-carbonyl chloride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.* Hazard Class: 8 UN Number: 3261 Packing Group: III IMO Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. Hazard Class: 8 UN Number: 3261 Packing Group: III RID/ADR Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S. Hazard Class: 8 UN Number: 3261 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 263157-86-4: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 263157-86-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 263157-86-4 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R34
• 安全声明 (欧洲): S26-S36/37/39-S45
• 危险品运输编码: UN 3261

合成路线

263157-83-1 ~% 263157-86-4

文献：Amgen Inc. Patent: US2004/157845 A1, 2004 ; Location in patent: Page 21 ; US 20040157845 A1

17518-49-9 ~% 263157-86-4

文献：Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495

263015-68-5 ~% 263157-86-4

文献：Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495

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