37065-29-5

• 常用中文名：米洛沙星
• 常用英文名：miloxacin
• CAS号：37065-29-5
• 分子式：C₁₂H₉NO₆
• 分子量：263.203
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-04-24 08:00:00
• 更新时间：2026-07-15 08:40:49

名称

• 中文名: 米洛沙星
• 英文名: 5-methoxy-8-oxo-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
• 中文别名: 米洛沙星标准品; 米罗沙星
• 英文别名: 5,8-Dihydro-5-methoxy-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-cboxylic acid; Miloxacin (inn); Antibiotic AB 206; Miloxacin; AB 206; Miloxacin Standd; AB-206; 1,3-Dioxolo[4,5-g]quinoline-7-cboxylic acid, 5,8-dihydro-5-methoxy-8-oxo; Miloxacin //BP; D02303; 5-Methoxy-8-oxo-5,8-dihydro[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid; 1,4-Dihydro-1-methoxy-6,7-methylenebisoxy-4-oxo-3-quinolinecboxylic acid; Antibiotic AB-206

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 460.9±55.0 °C at 760 mmHg
• 熔点: 264° (dec)
• 分子式: C₁₂H₉NO₆
• 分子量: 263.203
• 闪点: 232.5±31.5 °C
• 精确质量: 263.042999
• PSA: 86.99000
• LogP: 1.34
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.689

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : JI5060000 CHEMICAL NAME : 1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 5,8-dihydro-5-methoxy-8-oxo- CAS REGISTRY NUMBER : 37065-29-5 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C12-H9-N-O6 MOLECULAR WEIGHT : 263.22 WISWESSER LINE NOTATION : T C566 DO FO JN MV EHJ JO1 LVQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 36400 mg/kg/26W-I TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in uterine weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 413 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1650 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3300 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 8100 mg/kg SEX/DURATION : female 17-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - physical MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 140 ug/L REFERENCE : AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 17,763,1980

安全

• 海关编码: 2934999090

合成路线

37065-18-2 ~% 37065-29-5

文献：Agui,H. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 791 - 796

26893-17-4 ~% 37065-29-5

文献：Agui,H. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 791 - 796

58849-21-1 74-88-4 ~% 37065-29-5

文献：Agui,H. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 791 - 796

上下游产品

上游产品  4
37065-18-2 26893-17-4 58849-21-1 74-88-4
下游产品  0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%