10078-25-8

• 常用中文名：奋乃静亚砜
• 常用英文名：Perphenazine sulfoxide
• CAS号：10078-25-8
• 分子式：C₂₁H₂₆ClN₃O₂S
• 分子量：419.96800
• 相关类别： 研究领域 神经疾病
• 发布时间：2017-03-16 16:03:15
• 更新时间：2024-02-04 09:22:47
• Perphenazine sulfoxide 是 Perphenazine 的亚砜代谢物,由 Perphenazine 氧化形成。

名称

• 中文名: 奋乃静亚砜
• 英文名: perphenazine sulfoxide (100 mg)
• 英文别名: 4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethanosulfoxide; 2-chloro-10-(3-(4-(2-hydroxyethyl)-7-piperazinyl)propyl)phenothiazine; 10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-2-chloro-10H-phenothiazine 5-oxide; etaperazine S-oxide; 1-Piperazineethanol,4-(3-(2-chlorophenothiazin-10-yl)propyl)-,sulfoxide; Perphenazine Sulfate; perphenazine sulfoxide; Perphenazinsulfoxid; perpherazine sulfoxide

物化性质

• 密度: 1.41g/cm3
• 沸点: 624.8ºC at 760mmHg
• 分子式: C₂₁H₂₆ClN₃O₂S
• 分子量: 419.96800
• 闪点: 331.7ºC
• 精确质量: 419.14300
• PSA: 66.23000
• LogP: 3.76470
• 蒸汽压: 1.78E-16mmHg at 25°C
• 折射率: 1.71

生物活性

• 描述: Perphenazine sulfoxide 是 Perphenazine 的亚砜代谢物,由 Perphenazine 氧化形成。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. L B Hansen, et al. Plasma concentrations of perphenazine and its sulphoxide metabolite during continuous oral treatment. Psychopharmacology (Berl). 1977 Jul 18;53(2):127-30.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TL7700000 CHEMICAL NAME : 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, sulfoxide CAS REGISTRY NUMBER : 10078-25-8 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C21-H26-Cl-N3-O2-S MOLECULAR WEIGHT : 420.01 WISWESSER LINE NOTATION : T C666 BN ISJ EG IO B3- AT6N DNTJ D2Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 127 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 69 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,638,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 52500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

58-39-9 ~96% 10078-25-8

文献：Owens; Juenge; Poklis Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 4 p. 334 - 336

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