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Product Name: Perphenazine Sulfoxide
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10078-25-8

10078-25-8 structure

10078-25-8 structure

Name: Perphenazine sulfoxide
Chemical Name: perphenazine sulfoxide (100 mg)
CAS Number: 10078-25-8
Molecular Formula: C₂₁H₂₆ClN₃O₂S
Molecular Weight: 419.96800
Catalog: Research Areas Neurological Disease
Create Date: 2017-03-16 16:03:15
Modify Date: 2024-02-04 09:22:47
Perphenazine sulfoxide is a sulphoxide metabolite of Perphenazine, formed by the oxidation of Perphenazine[1].

Name	perphenazine sulfoxide (100 mg)
Synonyms	4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazineethanosulfoxide 2-chloro-10-(3-(4-(2-hydroxyethyl)-7-piperazinyl)propyl)phenothiazine 10-[3-[4-(2-Hydroxyethyl)-1-piperazinyl]propyl]-2-chloro-10H-phenothiazine 5-oxide etaperazine S-oxide 1-Piperazineethanol,4-(3-(2-chlorophenothiazin-10-yl)propyl)-,sulfoxide Perphenazine Sulfate perphenazine sulfoxide Perphenazinsulfoxid perpherazine sulfoxide

Description	Perphenazine sulfoxide is a sulphoxide metabolite of Perphenazine, formed by the oxidation of Perphenazine[1].
Related Catalog	Research Areas >> Neurological Disease
References	[1]. L B Hansen, et al. Plasma concentrations of perphenazine and its sulphoxide metabolite during continuous oral treatment. Psychopharmacology (Berl). 1977 Jul 18;53(2):127-30.

Density	1.41g/cm3
Boiling Point	624.8ºC at 760mmHg
Molecular Formula	C₂₁H₂₆ClN₃O₂S
Molecular Weight	419.96800
Flash Point	331.7ºC
Exact Mass	419.14300
PSA	66.23000
LogP	3.76470
Vapour Pressure	1.78E-16mmHg at 25°C
Index of Refraction	1.71

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL7700000

CHEMICAL NAME :: 1-Piperazineethanol, 4-(3-(2-chlorophenothiazin-10-yl)propyl)-, sulfoxide

CAS REGISTRY NUMBER :: 10078-25-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C21-H26-Cl-N3-O2-S

MOLECULAR WEIGHT :: 420.01

WISWESSER LINE NOTATION :: T C666 BN ISJ EG IO B3- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 127 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 69 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 10,638,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 68 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 52500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,37,1972

RIDADR	NONH for all modes of transport

58-39-9 structure

58-39-9

~96%

10078-25-8 structure

10078-25-8

Literature: Owens; Juenge; Poklis Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 4 p. 334 - 336

Precursor 1
58-39-9
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