41767-29-7

• 常用中文名：Fluocortin butyl ester
• 常用英文名：Fluocortin butyl ester
• CAS号：41767-29-7
• 分子式：C₂₆H₃₅FO₅
• 分子量：446.55
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2016-01-08 14:44:46
• 更新时间：2024-01-04 00:13:54
• 氟考替丁丁酯是一种开发的皮质类固醇化合物,局部使用时没有检测到全身皮质类固醇活性。氟考替丁丁酯似乎是一种有效且耐受性良好的局部类固醇,可用于常年性鼻炎的研究[1]。

名称

• 英文名: butyl 2-[(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoacetate
• 英文别名: SH K 203; Fluocortin butyl [USAN:BAN]; Vaspit; Varlane; EINECS 255-543-8; Fluocortin butyl (USAN); FLUOCORTIN BUTYL; fluocortin butylester

物化性质

• 分子式: C₂₆H₃₅FO₅
• 分子量: 446.55
• 精确质量: 446.24700
• PSA: 80.67000
• LogP: 3.98770

生物活性

• 描述: 氟考替丁丁酯是一种开发的皮质类固醇化合物,局部使用时没有检测到全身皮质类固醇活性。氟考替丁丁酯似乎是一种有效且耐受性良好的局部类固醇,可用于常年性鼻炎的研究[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体内研究: 即使重复皮下注射或口服剂量高达100 mg/kg的氟考替丁丁酯,也不会降低动物对微生物感染的抵抗力【2】。
• 参考文献:

  [1]. Hartley TF, et al. Efficacy and tolerance of fluocortin butyl administered twice daily in adult patients with perennial rhinitis. J Allergy Clin Immunol. 1985;75(4):501-507.

  [2]. [2] Kessler HJ et al. Tierexperimentelle Untersuchungen über den Einfluss von Fluocortin-butylester auf den Verlauf generalisierter Infektionen [Experimental studies in animals on the influence of fluocortin butylester on the course of generalized infections (author's transl)]. Arzneimittelforschung. 1977;27(11a):2214-2216.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU4155000 CHEMICAL NAME : Pregna-1,4-dien-21-oic acid, 6-fluoro-11-hydroxy-16-methyl-3,20-dioxo-, butyl ester, (6-alpha,11-beta,16-alpha)- CAS REGISTRY NUMBER : 41767-29-7 LAST UPDATED : 199103 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C26-H35-F-O5 MOLECULAR WEIGHT : 446.61 WISWESSER LINE NOTATION : L E5 B666 CV OV AHTTT&J A1 E1 FVVO4 G1 LF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2217,1977