1480-19-9

• 常用中文名：氟阿尼酮
• 常用英文名：fluanisone
• CAS号：1480-19-9
• 分子式：C₂₁H₂₅FN₂O₂
• 分子量：356.434
• 相关类别： 原料药 神经系统用药 抗精神病药
• 发布时间：2018-07-05 01:07:33
• 更新时间：2024-01-08 11:52:33
• Fluanisone is a typical antipsychotic and sedative of the butyrophenone chemical class. It is used in the treatment of schizophrenia and mania. It is also a component (along with fentanyl) of the injectable veterinary formulation fentanyl/fluanisone (Hypnorm) where it is used for rodent analgesia during short surgical procedures.

名称

• 中文名: 氟苯丙酮哌嗪
• 英文名: 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one
• 中文别名: 氟阿尼酮
• 英文别名: 1-Butanone, 1- (4-fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-; Butyrophenone, 4'-fluoro-4-[4- (o-methoxyphenyl)-1-piperazinyl]-; Anti-Pica; 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)-piperazine-1-yl]butan-1-one; Haloanisone; N1-(2-Methoxy-phenyl)-N4-<3-(4-fluor-benzoyl)-propyl>-piperazin; 1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-; 1-(4-fluoro-phenyl)-4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butan-1-one; MD 2028; 4'-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone; Fluanisonum [INN-Latin]; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone; Sedalande; Fluanison; Metorin; 4-[4-(o-Methoxyphenyl)-1-piperazinyl]-p-fluorobutyrophenone; 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one; fluanisone; Haloanison

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 511.8±50.0 °C at 760 mmHg
• 熔点: 67.5-68.5°
• 分子式: C₂₁H₂₅FN₂O₂
• 分子量: 356.434
• 闪点: 263.3±30.1 °C
• 精确质量: 356.190002
• PSA: 32.78000
• LogP: 3.43
• 外观性状: 固体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.558
• 储存条件: -20°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:3.6

  2.氢键供体数量:0

  3.氢键受体数量:5

  4.可旋转化学键数量:7

  5.互变异构体数量:2

  6.拓扑分子极性表面积:32.8

  7.重原子数量:26

  8.表面电荷:0

  9.复杂度:432

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EU3640000 CHEMICAL NAME : Butyrophenone, 4'-fluoro-4-(4-(o-methoxyphenyl)-1-piperazinyl)- CAS REGISTRY NUMBER : 1480-19-9 BEILSTEIN REFERENCE NO. : 0707524 LAST UPDATED : 199612 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C21-H25-F-N2-O2 MOLECULAR WEIGHT : 356.48 WISWESSER LINE NOTATION : T6N DNTJ A3VR DF& DR BO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 420 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Autonomic Nervous System - central sympatholytic Behavioral - alteration of classical conditioning REFERENCE : MDCHAG Medicinal Chemistry: A Series of Monographs. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1963- Volume(issue)/page/year: 4(2),199,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy) REFERENCE : APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 40,159,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 32,2241,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >80 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 3,432,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : >10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,932,1961 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 132 mg/kg SEX/DURATION : female 15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,199,1980 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974

安全

• 海关编码: 2933599090

合成路线

857-62-5 ~92% 1480-19-9

文献：Narsaiah, A. Venkat; Nagaiah; Devi, B. Karuna Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 4 p. 829 - 832

459-57-4 ~% 1480-19-9

文献：Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832

86718-78-7 ~% 1480-19-9

文献：Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832

1143515-07-4 ~% 1480-19-9

文献：Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832

1402042-55-0 ~% 1480-19-9

文献：Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832

1402042-56-1 ~% 1480-19-9

文献：Journal of Heterocyclic Chemistry, , vol. 49, # 4 p. 829 - 832

上下游产品

上游产品  5
857-62-5 459-57-4 86718-78-7 1143515-07-4
1402042-56-1
下游产品  0

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%