42061-52-9

• 常用中文名：嘌嘧替派
• 常用英文名：Pumitepa
• CAS号：42061-52-9
• 分子式：C₁₂H₁₉N₈OP
• 分子量：322.30600
• 发布时间：2018-08-27 23:03:52
• 更新时间：2024-01-17 07:18:56

名称

• 中文名: 嘌嘧替派
• 英文名: Pumitepa
• 英文别名: <32P>-Fopunic; 6-Diethylenimidophosphoamido-2-dimethylamino-7-methylpurin; bis-aziridin-1-yl-phosphinic acid 2-dimethylamino-7-methyl-7H-purin-6-ylamide; Bis(1-aziridinyl)[[2-(dimethylamino)-7-methyl-7H-purin-6-yl]amino]phosphine oxide

物化性质

• 密度: 1.7g/cm3
• 沸点: 528.7ºC at 760mmHg
• 分子式: C₁₂H₁₉N₈OP
• 分子量: 322.30600
• 闪点: 273.5ºC
• 精确质量: 322.14200
• PSA: 91.77000
• LogP: 0.52930
• 折射率: 1.828

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SZ5827000 CHEMICAL NAME : Phosphinic amide, P,P-bis(1-aziridinyl)-N-(2-(dimethylamino)-7-methyl-7 H-purin-6-yl)- CAS REGISTRY NUMBER : 42061-52-9 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C12-H19-N8-O-P MOLECULAR WEIGHT : 322.36 WISWESSER LINE NOTATION : T56 BN DN FN HNJ B1 GN1&1 IMPO&- AT3NTJ&- AT3NTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 175 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 24 mg/kg REFERENCE : BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 102(7),76,1986