360-65-6

• 常用中文名：甘氨脱氧胆酸
• 常用英文名：GLYCODEOXYCHOLIC ACID
• CAS号：360-65-6
• 分子式：C₂₆H₄₅NO₆
• 分子量：467.63900
• 相关类别： 天然产物 甾体化合物
• 发布时间：2018-08-22 14:38:18
• 更新时间：2026-07-01 21:15:03

• 诱发肝细胞凋亡，可能引起DNA分裂。

名称

• 中文名: 甘氨脱氧胆酸
• 英文名: glycodeoxycholic acid
• 中文别名: 甘氨胆酸杂质2; 乙醇脱氧胆酸(2,2,4,4,11,11-D6,)100UG/M L甲醇溶液; N-(3Α,12Α-二羟基-24-氧胆)甘氨酸; 苷氨脱氧胆酸; 甘油脱氧胆酸; 甘氨脱氧胆酸/甘氨脱氧胆酸一水合物; 甘氨去氧胆酸; 甘氨脱氧胆酸,10 MM DMSO 溶液; 氘6-甘去氧胆酸; 氘6-甘氨脱氧胆酸; 甘氨脱氧胆酸 (2,2,4,4,11,11-D6, ); 甘脱氧胆酸; 甘氨脱氧胆酸(GDCA); 甘氨异熊去氧胆酸酸; 甲醇中甘氨脱氧胆酸-D6同位素; N-(3Α,12Α-二羟基-24-氧胆)甘氨酸/甘油脱氧胆酸/甘氨脱氧胆酸一水合物/甘氨去氧胆酸; 甘氨脱氧胆酸对照品; 甘氨脱氧胆酸 -6; 甘氨酸胆酸; 乙二醛胆酸(水合物); 甘氨脱氧胆酸一水合物; 乙腈中甘氨去氧胆酸标准溶液
• 英文别名: N-[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]-Glycine; 2-[4-[(3R,5R,10R,12S,13R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentylamino]ethanoic acid; deoxycholicacidglycineconjugate; Glycodeoxycholic acid Monohydrate (GDCA); 3α,12α-Dihydroxy-5β-cholanoic acid N-(cboxymethyl)amide; GDCA)Glycodeoxycholic acid Monohy; 5β-Cholan-24-Oic Acid N-(Cboxymethyl)-Amide-3α,12α-Diol; Glycine, N-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]; GLYCODEOXYCHOLIC ACID FREE ACID; Glycodeoxycholic acid monohydrate,3α,12α-Dihydroxy-5β-cholanoic acid N-(cboxymethyl)amide, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine; N-Cboxymethyl-3α,12α-dihydroxy-5β-cholane-24-amide; MFCD00150922; 5BETA-CHOLAN-24-OIC ACID N-[CBOXYMETHYL]AMIDE-3ALPHA,12ALPHA-DIOL; N-[3ALPHA,12ALPHA-DIHYDROXY-24-OXOCHOLAN-24-YL]GLYCINE; glycodeoxy-5-beta-cholan-24-oicaci; Glycine deoxycholic acid; D5-Glycodeoxycholic Acid; 3ALPHA,12ALPHA-DIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-[CBOXYMETHYL]AMIDE; N-(3α,12α-Dihydroxy-24-oxo-5β-cholan-24-yl)glycine; 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)acetic acid; 5β-CHOLANIC ACID-3α, 12α-DIOL N-(CBOXYMETHYL)-AMIDE; 5BETA-CHOLANIC ACID-3ALPHA,12ALPHA-DIOL-24-N-(CBOXYETHYL)-AMIDE; DEOXYGLYCOCHOLIC ACID; 2-[[(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid; n-((3-alpha,5-beta,12-alpha)-3,12-dihydroxy-24-oxocholan-24-yl)-glycine; GLYCODESOXYCHOLIC ACID; 3α,12α-Dihydroxy-5β-cholanoic acid N-(cboxymethyl)amide, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine; glycodeoxycholicaci; n-(3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-yl)-glycin; deoxycholylglycine; GLYCODEOXYCHOLIC ACID, 10 mM in DMSO; N-(3a,12a-Dihydroxy-24-oxocholan-24-yl)glycine; D6-Glycodeoxycholic Acid; 3α,12α-Dihydroxy-5β-cholanoic acid N-(cboxymethyl)amide Glycodesoxycholic acid N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine GDCA; Glycodeoxycholic acid hydrate; 5-BETA-CHOLANIC ACID-3-ALPHA, 12-ALPHA-DIOL N-(CBOXYMETHYL)-AMIDE; GLYCODEOXYCHOLATE; Glycodeoxycholic acid monohydrate; Glycodeoxycholic Acid MaxSpec Standd; N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine; N-(3α,12α-Dihydroxy-24-oxo-5β-cholane-24-yl)glycine; Glycodeoxycholic acid; Glycerodeoxycholic acid; Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine, 3α,12α-Dihydroxy-5β-cholanoic acid N-(cboxymethyl)amide; glykodesoxycholsaeure; 2-[4-[(3R,5R,10R,12S,13R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentylamino]acetic acid; Glycine, N-[(3a,5b,12a)-3,12-dihydroxy-24-oxocholan-24-yl]

物化性质

• 密度: 1.162 g/cm3
• 沸点: 655.6ºC at 760 mmHg
• 分子式: C₂₆H₄₅NO₆
• 分子量: 467.63900
• 闪点: 350.3ºC
• 精确质量: 467.32500
• PSA: 116.09000
• LogP: 3.92070
• 外观性状: 白色固体
• 折射率: 1.546
• 储存条件: 室温
• 分子结构:

  1、 摩尔折射率：122.54

  2、 摩尔体积（cm³/mol）：386.8

  3、 等张比容（90.2K）：1019.5

  4、 表面张力（dyne/cm）：48.2

  5、 极化率（10-24cm3）：48.57

• 更多:

  一、物性数据

  性状：不可用

  密度（g/mL,25/4℃）：不可用

  相对蒸汽密度（g/mL,空气=1）：不可用

  熔点（ºC）：不可用

  沸点（ºC,常压）：不可用

  沸点（ºC,5.2kPa）：不可用

  折射率：不可用

  闪点（ºC）：不可用

  比旋光度（º）：不可用

  自燃点或引燃温度（ºC）：不可用

  蒸气压（kPa,25ºC）：不可用

  饱和蒸气压（kPa,60ºC）：不可用

  燃烧热（KJ/mol）：不可用

  临界温度（ºC）：不可用

  临界压力（KPa）：不可用

  油水（辛醇/水）分配系数的对数值：不可用

  爆炸上限（%,V/V）：不可用

  爆炸下限（%,V/V）：不可用

  溶解性：不可用

毒性和生态

毒理学数据: 二、毒理学数据： 急性毒性：不可用。 生态学数据: 三、生态学数据： 1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。 CHEMICAL IDENTIFICATION RTECS NUMBER : MB9670000 CHEMICAL NAME : Glycine, N-(3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-yl)- CAS REGISTRY NUMBER : 360-65-6 LAST UPDATED : 198803 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C26-H43-N-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,323,1970

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: MB9670000

合成路线

56-40-6 ~% 360-65-6

文献：Journal of the American Chemical Society, , vol. 59, p. 2532 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 106, p. 181,185

174069-00-2 ~% 360-65-6

文献：Letters in Drug Design and Discovery, , vol. 9, # 6 p. 573 - 580

83-44-3 ~% 360-65-6

文献：Arkiv foer Kemi, , vol. 8, p. 331,338

70779-06-5 ~% 360-65-6

文献：Bioorganic and Medicinal Chemistry, , vol. 4, # 6 p. 885 - 890

2287-93-6 ~% 360-65-6

文献：Annales Pharmaceutiques Francaises, , vol. 5, p. 556,563 Journal of Biological Chemistry, , vol. 113, p. 779,780

86678-83-3 56-40-6 ~% 360-65-6

文献：Annales Pharmaceutiques Francaises, , vol. 5, p. 556,563 Journal of Biological Chemistry, , vol. 113, p. 779,780

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