3131-03-1

• 常用中文名：普那霉素IA
• 常用英文名：Virginiamycin B
• CAS号：3131-03-1
• 分子式：C₄₅H₅₄N₈O₁₀
• 分子量：866.95800
• 相关类别： 多肽产品
• 发布时间：2018-02-26 08:00:00
• 更新时间：2024-01-01 17:16:03
• Pristinamycin IA是一个环肽大环内酯抗生素,属于 链霉杀阳菌素,也是P-glycoprotein的底物。

名称

• 中文名: 维及霉素B
• 英文名: pristinamycin IA
• 英文别名: Antibiotic PA 114B; Mikamycin B; Ostreogrycin B; PA 114B; Pristinamycin IA; Antibiotic PA 114 B1; Vernamycin BA; Mikamycin IA; Streptogramin B

物化性质

• 密度: 1.38g/cm3
• 沸点: 1202.1ºC at 760mmHg
• 分子式: C₄₅H₅₄N₈O₁₀
• 分子量: 866.95800
• 闪点: 680.8ºC
• 精确质量: 866.39600
• PSA: 227.96000
• LogP: 2.13220
• 储存条件: -20°C

生物活性

• 描述: Pristinamycin IA是一个环肽大环内酯抗生素,属于 链霉杀阳菌素,也是P-glycoprotein的底物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
  多肽产品
• 参考文献:

  [1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZA4870000 CHEMICAL NAME : Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)- CAS REGISTRY NUMBER : 3131-03-1 BEILSTEIN REFERENCE NO. : 0078387 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C45-H54-N8-O10 MOLECULAR WEIGHT : 867.07 WISWESSER LINE NOTATION : T F5-19-6 ANV DNV JNV MMV QOV TMV A&VTJ C1R DN1&1& D1 L2 P1 SR& OMV- BT6NJ CQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,367,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

安全

• 危险品运输编码: UN 3172
• 包装等级: III
• 危险类别: 6.1(b)