3131-03-1

3131-03-1 structure

Name: Virginiamycin B
Chemical Name: pristinamycin IA
CAS Number: 3131-03-1
Molecular Formula: C₄₅H₅₄N₈O₁₀
Molecular Weight: 866.95800
Catalog: Peptides
Create Date: 2018-02-26 08:00:00
Modify Date: 2025-08-27 16:32:09
Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]

Name	pristinamycin IA
Synonyms	Antibiotic PA 114B Mikamycin B Ostreogrycin B PA 114B Pristinamycin IA Antibiotic PA 114 B1 Vernamycin BA Mikamycin IA Streptogramin B

Description	Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein.In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). The basolateral to apical transport of [14C]pristinamycin IA is 100-fold higher than apical to basolateral passage. [1]
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others Peptides
References	[1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

CHEMICAL NAME :: Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)-

WISWESSER LINE NOTATION :: T F5-19-6 ANV DNV JNV MMV QOV TMV A&VTJ C1R DN1&1& D1 L2 P1 SR& OMV- BT6NJ CQ

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,367,1978

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967