21062-28-2

• 常用中文名：Guanidine,N-(3,4-dichlorophenyl)-N'-[4-[(1-ethyl-3-piperidinyl)amino]-6-methyl-2-pyrimidinyl]-
• 常用英文名：Guanidine,N-(3,4-dichlorophenyl)-N'-[4-[(1-ethyl-3-piperidinyl)amino]-6-methyl-2-pyrimidinyl]-
• CAS号：21062-28-2
• 分子式：C₁₉H₂₅Cl₂N₇
• 分子量：422.35500
• 相关类别： 研究领域 癌症
• 发布时间：2016-12-11 10:16:52
• 更新时间：2024-04-03 19:57:21
• SKOG102是一种有效的OLIG2抑制剂,它直接与OLIG2结合并干扰OLIG2与DNA结合的能力。SKOG102可用于胶质母细胞瘤(GBM)的研究[1]。

名称

• 英文名: 1-(3,4-dichlorophenyl)-2-[4-[(1-ethylpiperidin-3-yl)amino]-6-methylpyrimidin-2-yl]guanidine
• 英文别名: 1-(3,4-dichlorophenyl)-2-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-pyrimidin-2-yl]guanidine; 1-(3,4-Dichlorophenyl)-3-[4-[(1-ethyl-3-piperidyl)amino]-6-methyl-2-pyrimidinyl]guanidine

物化性质

• 密度: 1.4g/cm3
• 沸点: 609.7ºC at 760mmHg
• 分子式: C₁₉H₂₅Cl₂N₇
• 分子量: 422.35500
• 闪点: 322.5ºC
• 精确质量: 421.15500
• PSA: 88.96000
• LogP: 4.70340
• 蒸汽压: 8.31E-15mmHg at 25°C
• 折射率: 1.67

生物活性

• 描述: SKOG102是一种有效的OLIG2抑制剂,它直接与OLIG2结合并干扰OLIG2与DNA结合的能力。SKOG102可用于胶质母细胞瘤(GBM)的研究[1]。
• 相关类别:
  研究领域 >> 癌症
• 靶点:

  OLIG2[1]

• 体外研究: SKOG102(0.1-5μM；72小时)抑制人 国标4和 GBM8标准细胞生长为神经球,国际50分别为 10.66和 1.536μM[1]SKOG102(0.5-5μM；12小时)增加 国标4细胞中的 p21 RNA水平并降低 OMG RNA水平[1]。 SKOG102(5μM；20小时)抑制 OLIG2-DNA基因结合,并降低 GBM8标准细胞中的丝氨酸磷酸化 奥利2和总 奥利2蛋白水平[1]。
• 体内研究: SKOG102(10-20mg/kg；腹腔注射)抑制小鼠 国标4肿瘤的生长[1]。 SKOG102(5 mg/kg；腹腔注射)即使在相对较短的时间内也会在肿瘤中积聚,注射小鼠后 4.小时血浆和脑浓度几乎相同[1]。 动物模型：NSG小鼠每侧接种GBM4细胞[1]剂量：10、15和20 mg/kg；溶于溶质：PEG400：水(20%:40%:40%)给药：腹膜内注射；前2周(从第33天到第46天)10mg/kg,第3周(从47天到第54天)15mg/kg,第4周(从55天到第66天)前3天20mg/kg,休息2天,然后从第60天到66天交替几天。结果：显著减少肿瘤生长。
• 参考文献:

  [1]. Tsigelny IF, et, al. Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma. Oncotarget. 2017 Apr 4;8(14):22370-22384.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MF0405000 CHEMICAL NAME : Guanidine, 1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)ami no)-6-methyl-2-pyrimi dinyl)- CAS REGISTRY NUMBER : 21062-28-2 LAST UPDATED : 198204 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C19-H25-Cl2-N7 MOLECULAR WEIGHT : 422.41 WISWESSER LINE NOTATION : T6N CNJ BMYUM&MR CG DG& D1 FM- CT6NTJ A2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1041 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1128 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 53 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 261 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,75,1974