173997-05-2

• 常用中文名：5-(氨甲基)-1-((S)-5,7-二氟-1,2,3,4-四氢-2-萘)-4-咪唑啉-2-硫酮
• 常用英文名：Nepicastat
• CAS号：173997-05-2
• 分子式：C₁₄H₁₅F₂N₃S
• 分子量：295.351
• 相关类别： 信号通路 代谢酶/蛋白酶 多巴胺β-羟化酶
• 发布时间：2018-07-07 15:47:31
• 更新时间：2026-07-06 22:34:35
• Nepicastat (SYN117; RS-25560-197)是多巴胺β羟化酶抑制剂,对牛和人的多巴胺β羟化酶的IC50分别为8.5nM和9.0nM。

名称

• 中文名: 内匹司他
• 英文名: 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione
• 中文别名: 5 - (氨甲基)-1 - ((S)-5,7 - 二氟-1,2,3,4 - 四氢-2 - 萘) - 4 - 咪唑啉-2 - 硫酮; 5-(氨甲基)-1-((S)-5,7-二氟-1,2,3,4-四氢-2-萘)-4-咪唑啉-2-硫酮,盐酸盐
• 英文别名: Nicastat (free base) (SYN-117); 5-(AMinoMethyl)-1-((S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthyl)-4-iMidazoline-2-thione; SYN117; Nicastat [inn]; 5-(Aminomethyl)-1-((2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-imidazole-2-thione; SYN117;RS-25560-197;SYN-117;SYN; Nicastat HCl; Nicastat; Nepitat; Nitat; 2H-Imidazole-2-thione, 5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro; (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thione; 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione; (S)-5-Aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-2,3-dihydro-2-thioxo-1H-imidazole Hydrochloride; S1583_Selleck; (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thione; SYN-117; RS-25560-197; (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydro-naphthalen-2-yl)-1H-imidazole-2(3H)-thi; nepicastat

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 401.8±55.0 °C at 760 mmHg
• 分子式: C₁₄H₁₅F₂N₃S
• 分子量: 295.351
• 闪点: 196.8±31.5 °C
• 精确质量: 295.095459
• PSA: 78.83000
• LogP: 2.31
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.665
• 储存条件: 2-8℃

生物活性

• 描述: Nepicastat (SYN117; RS-25560-197)是多巴胺β羟化酶抑制剂,对牛和人的多巴胺β羟化酶的IC50分别为8.5nM和9.0nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 多巴胺β-羟化酶
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Stanley WC, et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9.

  [2]. Stanley WC, et al. Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor. J Cardiovasc Pharmacol. 1998 Jun;31(6):963-70.

  [3]. Sabbah HN, et al. Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Circulation. 2000 Oct 17;102(16):1990-5.

  [4]. Beliaev A, et al. Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase. J Med Chem. 2006 Feb 9;49(3):1191-7.

安全

• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%