5053-14-5

• 常用中文名：8-苄基-1-氧-3,8-二氮杂螺[4,5]癸烷-2-酮
• 常用英文名：8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
• CAS号：5053-14-5
• 分子式：C₁₄H₁₈N₂O₂
• 分子量：246.30500
• 发布时间：2018-12-04 12:28:20
• 更新时间：2024-01-07 21:26:01

名称

• 中文名: 8-苄基-1-氧-3,8-二氮杂螺[4,5]癸烷-2-酮
• 英文名: 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
• 中文别名: 8-苄基-1-噁-3,8-二氮杂螺[4.5]-2-癸酮
• 英文别名: 8-benzyl-1-oxa-2-oxo-3,8-diazospiro<4,5>decane; 8-benzyl-1-oxa-3,8-diazaspiro<4.5>decan-2-one

物化性质

• 密度: 1.22g/cm3
• 沸点: 457.1ºC at 760 mmHg
• 分子式: C₁₄H₁₈N₂O₂
• 分子量: 246.30500
• 闪点: 230.2ºC
• 精确质量: 246.13700
• PSA: 45.06000
• LogP: 1.33890
• 折射率: 1.6
• 储存条件: 2-8°C，密封，干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RO0220000 CHEMICAL NAME : 1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-benzyl- CAS REGISTRY NUMBER : 5053-14-5 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C14-H18-N2-O2 MOLECULAR WEIGHT : 246.34 WISWESSER LINE NOTATION : T6N CXTJ A1R& C-& DT5MVOX EHJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 319 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,185,1969

安全

• 海关编码: 2934999090

合成路线

23804-68-4 ~% 5053-14-5

文献：Merck and Co., Inc. Patent: US6172076 B2, 2001 ; US 6172076 B1

77211-73-5 ~% 5053-14-5

文献：Caroon; Clark; Kluge; Nelson; Strosberg; Unger; Michel; Whiting Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1320 - 1328

32315-10-9 23804-68-4 ~74% 5053-14-5

文献：Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487

6094-60-6 ~% 5053-14-5

文献：Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345

3612-20-2 ~% 5053-14-5

文献：Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487

156215-49-5 ~% 5053-14-5

文献：Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487

23804-68-4 105-58-8 ~% 5053-14-5

文献：Regnier,G. et al. Chimica Therapeutica, 1969 , vol. 4, p. 185 - 194

23804-68-4 530-62-1 ~% 5053-14-5

文献：Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345

上下游产品

上游产品  7
23804-68-4 77211-73-5 32315-10-9 6094-60-6
3612-20-2 105-58-8 530-62-1
下游产品  6
23804-85-5 23804-80-0 77225-15-1 5052-95-9
5053-04-3 5229-89-0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%