8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Modify Date: 2025-08-24 23:36:14

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure
8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one structure
 Common Name 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
CAS Number 5053-14-5 Molecular Weight 246.30500
Density 1.22g/cm3 Boiling Point 457.1ºC at 760 mmHg
Molecular Formula C14H18N2O2 Melting Point N/A
MSDS N/A Flash Point 230.2ºC

 Names

Name 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.22g/cm3
Boiling Point 457.1ºC at 760 mmHg
Molecular Formula C14H18N2O2
Molecular Weight 246.30500
Flash Point 230.2ºC
Exact Mass 246.13700
PSA 45.06000
LogP 1.33890
Index of Refraction 1.6
InChIKey IUIWIPRVGAAEOH-UHFFFAOYSA-N
SMILES O=C1NCC2(CCN(Cc3ccccc3)CC2)O1

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RO0220000
CHEMICAL NAME :
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-benzyl-
CAS REGISTRY NUMBER :
5053-14-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H18-N2-O2
MOLECULAR WEIGHT :
246.34
WISWESSER LINE NOTATION :
T6N CXTJ A1R& C-& DT5MVOX EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
319 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,185,1969

 Safety Information

HS Code 2934999090

 Synthetic Route

4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Merck and Co., Inc. Patent: US6172076 B2, 2001 ; US 6172076 B1
2-(1-benzyl-4-hydroxypiperidin-4-yl)acetohydrazide structure

2-(1-benzyl-4-h...

CAS#:77211-73-5

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Caroon; Clark; Kluge; Nelson; Strosberg; Unger; Michel; Whiting Journal of Medicinal Chemistry, 1981 , vol. 24, # 11 p. 1320 - 1328
Triphosgene structure

Triphosgene

CAS#:32315-10-9

4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

~74%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
1-benzyl-4-cyano-4-hydroxypiperidine structure

1-benzyl-4-cyan...

CAS#:6094-60-6

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345
N-Benzyl-4-piperidone structure

N-Benzyl-4-pipe...

CAS#:3612-20-2

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
1-Benzyl-4-((trimethylsilyl)oxy)piperidine-4-carbonitrile structure

1-Benzyl-4-((tr...

CAS#:156215-49-5

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Somanathan; Rivero; Nunez; Hellberg Synthetic Communications, 1994 , vol. 24, # 10 p. 1483 - 1487
4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

Ethyl carbonate structure

Ethyl carbonate

CAS#:105-58-8

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Regnier,G. et al. Chimica Therapeutica, 1969 , vol. 4, p. 185 - 194
4-(Aminomethyl)-1-benzyl-4-piperidinol structure

4-(Aminomethyl)...

CAS#:23804-68-4

N,N-Carbonyldiimidazole structure

N,N-Carbonyldii...

CAS#:530-62-1

~%

8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one Structure

8-Benzyl-1-oxa-...

CAS#:5053-14-5

Literature: Methot, Joey L.; Hoffman, Dawn Mampreian; Witter, David J.; Stanton, Matthew G.; Harrington, Paul; Hamblett, Christopher; Siliphaivanh, Phieng; Wilson, Kevin; Hubbs, Jed; Heidebrecht, Richard; Kral, Astrid M.; Ozerova, Nicole; Fleming, Judith C.; Wang, Hongmei; Szewczak, Alexander A.; Middleton, Richard E.; Hughes, Bethany; Cruz, Jonathan C.; Haines, Brian B.; Chenard, Melissa; Kenific, Candia M.; Harsch, Andreas; Secrist, J. Paul; Miller, Thomas A. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 4 p. 340 - 345

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

8-benzyl-1-oxa-2-oxo-3,8-diazospiro<4,5>decane
8-benzyl-1-oxa-3,8-diazaspiro<4.5>decan-2-one
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Chemsrc provides CAS#:5053-14-5 MSDS, density, melting point, boiling point, structure, etc. Its name is 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one>> amp version: 8-Benzyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

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