56001-37-7

• 常用中文名：三磷酸鸟苷二钠盐
• 常用英文名：Guanosine-5'-triphosphate disodium salt
• CAS号：56001-37-7
• 分子式：C₁₀H₁₄N₅Na₂O₁₄P₃
• 分子量：567.144
• 相关类别： 生物化工 核苷类药物 核苷中间体
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-01-02 20:08:45
• Guanosine-5'-triphosphate disodium salt (5'-GTP trisodium salt) 是 G 蛋白信号转导活化剂,也是 DNA 和 RNA 酶生物合成中单核苷单元的富能量前体。

名称

• 中文名: 鸟苷-5'-三磷酸二钠盐
• 英文名: Guanosine 5‘-triphosphate, disodium salt hydrate
• 中文别名: 三磷酸鸟苷二钠盐; 鸟苷-5'-三磷酸二钠; 5-鸟苷三磷酸二钠盐
• 英文别名: Disodium 5'-O-({[(phosphonooxy)phosphinato]oxy}phosphinato)guanosine; Guanosine, 5'-(tetrahydrogen triphosphate), sodium salt (1:2); Guanosine-5'-triphosphoric aicd disodium salt; MFCD00083629; EINECS 252-847-2

物化性质

• 沸点: 1028.3ºC at 760mmHg
• 熔点: 180°C
• 分子式: C₁₀H₁₄N₅Na₂O₁₄P₃
• 分子量: 567.144
• 闪点: 575.7ºC
• 精确质量: 566.954529
• PSA: 334.19000
• 外观性状: 无气味的白色固体
• 储存条件:

  密封、在 -20ºC下保存

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：-6.8

  2、 氢键供体数量：4

  3、 氢键受体数量：17

  4、 可旋转化学键数量：7

  5、 互变异构体数量：6

  6、 拓扑分子极性表面积（TPSA）：306

  7、 重原子数量：32

  8、 表面电荷：-4

  9、 复杂度：899

  10、同位素原子数量：0

  11、确定原子立构中心数量：4

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：1

• 更多:

  1. 性状：固体

  2. 密度（g/mL,15ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）： 未确定

  4. 熔点（ºC）：180

  5. 沸点（ºC）：未确定

  6. 沸点（ºC，0.5mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（°F）：未确定

  9. 比旋光度（ºC）：未确定

  10. 自燃点或引燃温度（ºC）： 未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Guanosine-5'-triphosphate disodium salt (5'-GTP trisodium salt) 是 G 蛋白信号转导活化剂,也是 DNA 和 RNA 酶生物合成中单核苷单元的富能量前体。
• 相关类别:
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Guanosine triphosphate.

MSDS

Name: Guanosine 5 -triphosphate disodium salt hydrate 95+% (hplc) Material Safety Data Sheet Synonym: GTP disodium sal CAS: 56001-37-7 Section 1 - Chemical Product MSDS Name:Guanosine 5 -triphosphate disodium salt hydrate 95+% (hplc) Material Safety Data Sheet Synonym:GTP disodium sal Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 56001-37-7 Guanosine 5'-triphosphate, disodium sa 259-940-7 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Moisture sensitive. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a tightly closed container. Keep under an argon blanket. Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Exposure Limits CAS# 56001-37-7: Personal Protective Equipment Eyes: Wear chemical splash goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron. Respirators: A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: Odorless pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 180 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: soluble in water Specific Gravity/Density: Molecular Formula: C10H14N5O14P3Na2.2H2O Molecular Weight: 567.14 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: High temperatures, incompatible materials, heating to decomposition, exposure to moist air or water. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, oxides of phosphorus, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 56001-37-7 unlisted. LD50/LC50: Not available. Carcinogenicity: Guanosine 5'-triphosphate, disodium salt dihydrate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Ecotoxicity: Water danger/protection: WGK 1 Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 56001-37-7: 1 Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 56001-37-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 56001-37-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 对水是稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 26-27-36/37/39
• WGK德国: 3