5382-49-0

• 常用中文名：1,2,3,4-四羟基-6-羧酸喹啉
• 常用英文名：1,2,3,4-Tetrahydroquinoline-6-carboxylic acid
• CAS号：5382-49-0
• 分子式：C₁₀H₁₁NO₂
• 分子量：177.200
• 发布时间：2018-12-22 20:46:04
• 更新时间：2024-01-02 17:52:50
• 下载msds

名称

• 中文名: 1,2,3,4-四氢喹啉-6-甲酸
• 英文名: 1,2,3,4-Tetrahydro-6-quinolinecarboxylic Acid
• 中文别名: 1,2,3,4-四羟基-6-羧酸喹啉
• 英文别名: 1,2,3,4-TETRAHYDRO-6-QUINOLINECARBOXYLIC ACID; 6-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-; 1,2,3,4-tetrahydroquinoline-6-carboxylic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 382.6±31.0 °C at 760 mmHg
• 熔点: 168ºC
• 分子式: C₁₀H₁₁NO₂
• 分子量: 177.200
• 闪点: 185.2±24.8 °C
• 精确质量: 177.078979
• PSA: 49.33000
• LogP: 2.40
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.587
• 储存条件: 2-8°C

MSDS

Name: 1 2 3 4-Tetrahydro-6-quinolinecarboxylic acid 97% Material Safety Data Sheet Synonym: CAS: 5382-49-0 Section 1 - Chemical Product MSDS Name:1 2 3 4-Tetrahydro-6-quinolinecarboxylic acid 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 5382-49-0 1,2,3,4-Tetrahydro-6-quinolinecarboxyl 97% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 5382-49-0: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: beige Odor: odorless - slight odor pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C10H11NO2 Molecular Weight: 177.2 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 5382-49-0 unlisted. LD50/LC50: Not available. Carcinogenicity: 1,2,3,4-Tetrahydro-6-quinolinecarboxylic acid - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 5382-49-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 5382-49-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 5382-49-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S37/39
• 海关编码: 2933499090

合成路线

10349-57-2 ~99% 5382-49-0

文献：Zhang, Cunyu; Westaway, Susan M.; Speake, Jason D.; Bishop, Michael J.; Goetz, Aaron S.; Carballo, Luz Helena; Hu, Mike; Epperly, Andrea H. Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 670 - 676

851202-94-3 ~61% 5382-49-0

文献：H. LUNDBECK A/S Patent: WO2005/39572 A1, 2005 ; Location in patent: Page/Page column 31-32 ;

50741-36-1 ~94% 5382-49-0

文献：Marchand, Pascal; Puget, Alain; Le Baut, Guillaume; Emig, Peter; Czech, Michael; Guenther, Eckhard Tetrahedron, 2005 , vol. 61, # 16 p. 4035 - 4041

635-46-1 ~% 5382-49-0

文献：Tetrahedron, , vol. 61, # 16 p. 4035 - 4041

22190-35-8 ~% 5382-49-0

文献：Tetrahedron, , vol. 61, # 16 p. 4035 - 4041

上下游产品

上游产品  5
10349-57-2 851202-94-3 50741-36-1 635-46-1
22190-35-8
下游产品  3
10349-57-2 177478-49-8 162648-46-6

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%