120014-30-4

• 常用中文名：5,6-二甲氧基-2-(哌啶-4-基)亚甲基-茚满-1-酮
• 常用英文名：5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one
• CAS号：120014-30-4
• 分子式：C₁₇H₂₃NO₃
• 分子量：289.369
• 发布时间：2018-11-24 13:04:09
• 更新时间：2026-07-08 12:50:36
• 【用途一】
  有机、医药合成中间体，可用于合成多奈哌齐。

名称

• 中文名: 5,6-二甲氧基-2-(4-哌啶基)亚甲基-1-茚酮
• 英文名: 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one
• 中文别名: 脱苄基多奈哌齐; 多奈哌齐杂质4 (多奈哌齐杂质A); 亚甲基吡啶加氢产物; 多奈哌齐杂质A; 多奈哌齐杂质10; 盐酸多奈哌齐中间体 5,6-二甲氧基-2-(4-哌啶基)亚甲基-1-茚酮; 多奈哌齐杂质20; 多奈哌齐杂质42; 哌啶茚满酮; 脱苄多奈哌齐; RSYY(阿哌沙班)-44; 脱苄基多奈哌齐(杂质A)
• 英文别名: Donezil Impurity 10; 5,6-DIMETHOXY-2-(PIPERIDIN-4-YL)METHYLENE-INDAN-1-ONE HCL; 5,6-DIMETHOXY-2-(PIPERIDINE-4-YL)METHYLENE-INDAN-1-ONE HCL; UNII:D84X9FAD1Y; 5,6-Dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone; 2,3-dihydro-5,6-dimethoxy-2-(4-piperidinyl)methyl-indan-1-one; Donezil Impurity 4 (Donezil Impurity A); 5,6-dimethoxy-2-(pyridin-4-ylmethylidene)-3H-inden-1-one; Donepezil Impurity 4; Donezil Desbenzyl Impurity - Free base; 4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]piperidine; 1H-INDEN-1-ONE, 2,3-DIHYDRO-5,6-DIMETHOXY-2-(4-PIPERIDINYLMETHYL); 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone; Donezil impurity 18/N-Debenzyl Donezil/5,6-Dimethoxy-2-(piperidin-4-yl)methylindan-1-one; Desbenzyl Donezil; 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one; 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one; Donezil Impurity A Donezil Desbenzyl Impurity; 5,6-dimethoxy-2-(piperidin-4-yl)methyl-indan-1-one; MFCD08460096; Donezil Impurity 42; N-Debenzyldonepezil; Desbenzyl Donezil (Donezil Impurity); 5,6-Dimethoxy-2-(Pyridin-4-yl)-Methyleneindan-1-One; 4-[(5,6-DIMETHOXY-1-INDANONE) -2-METHYL] PIPERIDINE; 2-[(4-piperidinyl)methyl]-5,6-dimethoxyindanone; 5,6-Dimethoxy-2-(piperidin-4-ylmethyl)indan-1-one; 5,6-Dimethoxy-2-(Pyridine-4-Yl)Methylene-Indan-1-OneHcl; 5,6-Dimethoxy-2-(Pyridine-4-Yl)Methylene-Indan-1-OneBase; ACHE-IN-38; UNII-D84X9FAD1Y; 5,6-Dimethoxy-2-(Piperidin-4-Ylmethyl)-2,3-Dihydroinden-1-One; debenzyldonezil

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 454.1±45.0 °C at 760 mmHg
• 熔点: 258-260°C (dec.)
• 分子式: C₁₇H₂₃NO₃
• 分子量: 289.369
• 闪点: 228.4±28.7 °C
• 精确质量: 289.167786
• PSA: 47.56000
• LogP: 2.88
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.538
• 储存条件: Refrigerator

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 海关编码: 2933399090

合成路线

上下游产品

上游产品  7
4803-57-0 120014-06-4 120014-07-5 948550-60-5
861675-47-0 2107-69-9 872-85-5
下游产品  1
120014-06-4

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%