553-27-5

• 常用中文名：N,N-双(2-氯乙基)苯胺
• 常用英文名：N,N-bis-(2-Chloroethyl)aniline
• CAS号：553-27-5
• 分子式：C₁₀H₁₃Cl₂N
• 分子量：218.12300
• 发布时间：2018-02-16 08:00:00
• 更新时间：2024-01-08 13:34:50

名称

• 中文名: N,N-双(2-氯乙基)苯胺
• 英文名: n,n-bis(2-chloroethyl)aniline
• 英文别名: Lymphoquine; Aniline mustard; Mesylerythrol; Lymphocin; Lymphochin; Lymphoquin; Lymphchin

物化性质

• 密度: 1.19 g/cm3
• 沸点: 304.1ºC at 760 mmHg
• 分子式: C₁₀H₁₃Cl₂N
• 分子量: 218.12300
• 闪点: 137.7ºC
• 精确质量: 217.04300
• PSA: 3.24000
• LogP: 2.97060
• 折射率: 1.563
• 储存条件: 库房通风低温干燥,与食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BW8225000 CHEMICAL NAME : Aniline, N,N-bis(2-chloroethyl)- CAS REGISTRY NUMBER : 553-27-5 BEILSTEIN REFERENCE NO. : 0880463 LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C10-H13-Cl2-N MOLECULAR WEIGHT : 218.14 WISWESSER LINE NOTATION : G2NR&2G HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 239 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 123 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/m3/10M TOXIC EFFECTS : Behavioral - irritability Lungs, Thorax, or Respiration - acute pulmonary edema TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 52 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 375 mg/kg/35D-I TOXIC EFFECTS : Behavioral - food intake (animal) Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring) Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 375 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death MUTATION DATA TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 30 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,78,1984

安全

• 危害码 (欧洲): C
• 海关编码: 2921420090

合成路线

22964-38-1 ~71% 553-27-5

文献：Lin, Song-Wen; Sun, Qi; Ge, Ze-Mei; Wang, Xin; Ye, Jia; Li, Run-Tao Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 940 - 943

120-07-0 ~91% 553-27-5

文献：Chen, Cheng; Wang, Ruyong; Guo, Liangqia; Fu, Nanyan; Dong, Haijun; Yuan, Yaofeng Organic Letters, 2011 , vol. 13, # 5 p. 1162 - 1165

91-66-7 ~% 553-27-5

文献：EP1679069 A1, ; Page/Page column 41 ;

6940-76-7 74497-02-2 ~0% 935-06-8 553-27-5

文献：Romera, Juan L.; Cid, Jose M.; Trabanco, Andres A. Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8797 - 8800

74497-02-2 ~% 553-27-5

文献：Journal of the Chemical Society, , p. 183,184

海关

海关编码	2921420090
中文概述	2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%