32988-50-4

• 常用中文名：紫霉素
• 常用英文名：Viomycin
• CAS号：32988-50-4
• 分子式：C₂₅H₄₃N₁₃O₁₀
• 分子量：685.69000
• 相关类别： 原料药 抗生素类药物 氨基糖苷类药
• 发布时间：2018-03-29 08:00:00
• 更新时间：2024-01-11 10:20:19
• 紫霉素是一种由灰色链霉菌紫色变种产生的一种多肽类抗生素。一般用作第二线抗结核药。仅对结核杆菌有较强的抑制作用。其抗菌机制是抑制细菌蛋白质的合成。对结核分枝杆菌(Mycobacteriumtuberculosis)的抗菌强度比链霉素弱，比对氨基水杨酸钠强，但对链霉素、卡那霉素和异烟肼耐药的菌株仍有效。一般与其他抗结核药物合并使用，以治疗由耐药菌引起的结核病。其抗结核作用与卷曲霉素相似，并与其有交叉耐药性。临床用于对异烟肼、链霉素无效的结核病患者。

名称

• 中文名: 紫霉素
• 英文名: viomycin
• 中文别名: 紫黴素
• 英文别名: Tuberactomycin B; Viomicina; Tuberactinomycin B; VIOMYCIN; Florimycin; (3S)-3,6-diamino-N-[(3S,6Z,9S,12S,15S)-3-[(4S,6R)-2-amino-4-hydroxy-1,4,5,6-tetrahydropyrimidin-6-yl]-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]hexanamide; Celiomycin; Viomycinum; Viomycine

物化性质

• 密度: 1.8g/cm3
• 沸点: 695.81°C (rough estimate)
• 熔点: 280°C (lit.)
• 分子式: C₂₅H₄₃N₁₃O₁₀
• 分子量: 685.69000
• 精确质量: 685.32600
• PSA: 392.86000
• 外观性状: 白色至米白色固体
• 折射率: 1.762
• 储存条件: Store at -20°C

生物活性

• 描述: 紫霉素是一种有效的抗分枝杆菌抗生素。当添加到积极参与多肽合成的纯化内源性大肠杆菌多聚体[1][2]中时,紫霉素快速抑制多肽链延长。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. FINLAY AC, et al. Viomycin a new antibiotic active against Mycobacteria. Am Rev Tuberc. 1951 Jan;63(1):1-3.

  [2]. Modolell J, Vázquez. The inhibition of ribosomal translocation by viomycin. Eur J Biochem. 1977 Dec;81(3):491-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZA3900000 CHEMICAL NAME : Viomycin CAS REGISTRY NUMBER : 32988-50-4 LAST UPDATED : 199609 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C25-H43-N13-O10 MOLECULAR WEIGHT : 685.81 WISWESSER LINE NOTATION : T-16-MVYMV GMV JMV NMVTJ CU1MVZ F1Q I1Q LMV1YZ3Z P- DT6MYMTJ BUM FQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1075 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,69,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,69,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1637 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,69,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 7 gm/kg SEX/DURATION : female 6-10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE. Volume(issue)/page/year: 14,107,1965