57866-21-4

• 常用中文名：Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-
• 常用英文名：Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS号：57866-21-4
• 分子式：C₂₀H₂₁NO₆
• 分子量：371.38400
• 发布时间：2016-09-28 10:44:41
• 更新时间：2024-03-04 09:19:53

名称

• 英文名: Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)
• 英文别名: 2,3-O-didemethylcolchicine; (S)-7-(Acetylamino)-6,7-dihydro-1,10-dimethoxy-2,3-dihydroxybenzo[a]heptalen-9(5H)-one; 2,3-Didemethylcolchicin; 2,3-Dimethylcolchicine; 2,3-didemethylcolchicine

物化性质

• 密度: 1.38g/cm3
• 沸点: 810.3ºC at 760mmHg
• 分子式: C₂₀H₂₁NO₆
• 分子量: 371.38400
• 闪点: 443.9ºC
• 精确质量: 371.13700
• PSA: 105.09000
• LogP: 2.65650
• 折射率: 1.642

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC8585750 CHEMICAL NAME : Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9- oxobenzo(a)heptalen-7 -yl)-, (S)- CAS REGISTRY NUMBER : 57866-21-4 LAST UPDATED : 199512 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C20-H21-N-O6 MOLECULAR WEIGHT : 371.42 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJCIB8 European Journal of Clinical Investigation. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1970- Volume(issue)/page/year: 22,630,1992

合成路线

7336-33-6 ~% 57866-21-4

文献：Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688

123417-71-0 ~30% 57866-21-4

文献：Muzaffar, Anjum; Chrzanowska, Maria; Brossi, Arnold Heterocycles, 1989 , vol. 28, # 1 p. 365 - 372

64-86-8 ~7% 7336-36-9 57866-21-4 78231-83-1

文献：Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260

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