7336-33-6

• 常用中文名：3-Demethylcolchicine
• 常用英文名：Desmethylcolchicine
• CAS号：7336-33-6
• 分子式：C₂₀H₂₃NO₅
• 分子量：357.40000
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2016-09-10 15:02:03
• 更新时间：2026-10-14 17:30:54
• 3-去甲基秋水仙碱是秋水仙碱的代谢产物,其碳环上有一个羟基,可以参与自由基清除,并显著抑制角叉菜胶水肿[1][2]。

名称

• 中文名: 3-去甲基秋水仙碱
• 英文名: N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• 中文别名: 秋水仙碱杂质E; 3-去甲秋水仙碱; 秋水仙碱杂质E/BP); 3-Demethylcolchicine #天然产物 HY-W021267; 3-去甲秋水仙碱,10 MM DMSO 溶液; (S)-N-(3-羟基-1,2,10-三甲氧基-9-氧代-5,6,7,9-四氢苯并[A]HTALEN-7-基)乙酰胺
• 英文别名: O3-Demethylcolchicine; Colchicine 3-Demethyl Impurity; Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2,10-trimethoxy-9-oxobenzo[a]htalen-7-yl]; 3-DesMethylcolchicine; Colchiciine,3-desmethyl; 3-O-Demethylcolchicine; 3-Demethylcolchicine; Colchicine,2-demethyl; Colchicine Impurity E; (S)-N-(3-hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl)acetamide; N-[(7S,12a)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl]acetamide (3; N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2,10-triMethoxy-9-oxobenzo[a]htalen-7-yl]-acetaMide; Colchicine Impurity E (3-O-Demethyl Colchicine); N-[[(7S)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalene]-7α-yl]acetamide; 3-Desmethylcolchicine; N-(3-hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl)acetamide; N-[(7S,12a)-3-Hydroxy-1,2,10-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]htalen-7-yl]acetamide (3-O-Demethylcolchicine); 3-demethylcolchicine, 10 mM in DMSO; N-[(7S)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]htalen-7-yl]acetamide; crageenin,3 demethylcolchicine,inhibit,Inhibitor,scavenging,colchicine,3-Demethylcolchicine,edema,Reactive Oxygen Species,metabolite,3demethylcolchicine,radical; (S)-7-Acetylamino-6,7-dihydro-3-hydroxy-1,2,10-trimethoxybenzo[a]htalen-9(5H)-one; Colchicine Impurity 5（Colchicine Impurity E）; (-)-3-Demethylcolchicine

物化性质

• 密度: 1.31g/cm3
• 沸点: 768.3ºC at 760 mmHg
• 熔点: 163-166ºC
• 分子式: C₂₀H₂₃NO₅
• 分子量: 357.40000
• 闪点: 418.5ºC
• 精确质量: 357.15800
• PSA: 84.86000
• LogP: 3.15700
• 折射率: 1.61
• 储存条件: 2-8°C，避光，干燥，密封

生物活性

• 描述: 3-去甲基秋水仙碱是秋水仙碱的代谢产物,其碳环上有一个羟基,可以参与自由基清除,并显著抑制角叉菜胶水肿[1][2]。
• 相关类别:
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Modriansky M, et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?. Toxicology. 2002;177(1):105-117.

  [2]. Sugio K, et al. Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners. Life Sci. 1987;40(1):35-39.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0880500 CHEMICAL NAME : Colchicine, 3-O-demethyl- CAS REGISTRY NUMBER : 7336-33-6 LAST UPDATED : 199112 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C21-H23-N-O6 MOLECULAR WEIGHT : 385.45 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EQ JMV1 NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 570 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981

安全

• 危害码 (欧洲): Xi

合成路线

477-29-2 ~89% 7336-33-6

文献：Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

64-86-8 ~% 7336-33-6

文献：Maier, Ulrich H.; Zenk, Meinhart H. Tetrahedron Letters, 1997 , vol. 38, # 42 p. 7357 - 7360

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