12067-99-1

• 常用中文名：磷钨酸
• 常用英文名：Phosphotungstic acid 44-hydrate
• CAS号：12067-99-1
• 分子式：H₃O₄₀PW₁₂
• 分子量：2880.05000
• 相关类别： 无机化工 无机酸
• 发布时间：2018-07-27 17:58:09
• 更新时间：2024-01-02 22:12:31
• 用作生化试剂及色谱分析试剂

名称

• 中文名: 磷钨酸
• 英文名: Phosphotungstic acid, 44-hydrate
• 中文别名: 磷鎢酸
• 英文别名: Phosphotungstic acid 44-hydrate; MFCD00041964; oxotungsten,hydroxide,phosphate; EINECS 235-087-6

物化性质

• 熔点: 89ºC
• 分子式: H₃O₄₀PW₁₂
• 分子量: 2880.05000
• 精确质量: 2881.20000
• PSA: 702.09000
• 外观性状: 灰白色结晶粉末
• 储存条件:

  常温密闭，阴凉通风干燥

• 稳定性:

  易潮解。与碱共沸时分解为磷酸盐和钨酸盐。含水量一般是在9～17分子之间。加氯水后加热很容易使还原产物再被氧化。虽然磷钨酸在水中的溶解度很大，但它可以被乙醚完全从水溶液中萃取出来。它和乙醚形成一比重很大的液层，这是一个乙醚与磷钨酸的复合物，既不溶于乙醚也不溶于水，因而当以过量乙醚来萃取水溶液时形成了三个液层。除了极易溶于水和乙醚之外，磷钨酸还易溶于低元醇和酯中。

• 水溶解性: PRACTICAL 不溶
• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：2881.204621 Da

  8、标称质量：2882 Da

  9、平均质量：2880.0536 Da

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:6

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积104

  7.重原子数量:8

  8.表面电荷:-4

  9.复杂度:38.8

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

• 更多:

  1. 性状：从水中（它极易溶于水）结晶为很重的白色八面体。它的水溶液对光线是不稳定的，由于还原作用的结果会缓慢地变为蓝色。

  2. 密度（g/mL,25℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，1mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：几乎不溶于水。

MSDS

Name: Phosphotungstic Acid Hydrate p.a. Material Safety Data Sheet Synonym: Phosphowolframic Acid; Tungstophosphoric Acid; Tungstate(3-), tetracosa-.mu.-oxododecaoxo[.mu.12-(phosphato(3-)-O:O:O:O':O':O' :O'':O'':O'':O''':O''':O''')]dodeca-, trihydrogen, hydrat CAS: 12067-99-1 Section 1 - Chemical Product MSDS Name:Phosphotungstic Acid Hydrate p.a. Material Safety Data Sheet Synonym:Phosphowolframic Acid; Tungstophosphoric Acid; Tungstate(3-), tetracosa-.mu.-oxododecaoxo[.mu.12-(phosphato(3-)-O:O:O:O':O':O' :O'':O'':O'':O''':O''':O''')]dodeca-, trihydrogen, hydrat Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 12067-99-1 Phosphotungstic Acid Hydrate, p.a. 100 unlisted Hazard Symbols: C Risk Phrases: 34 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Causes burns.Corrosive. Potential Health Effects Eye: Causes eye burns. Contact may cause ulceration of the conjunctiva and cornea. Skin: Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color. Ingestion: May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. Causes severe pain, nausea, vomiting, diarrhea, and shock. May cause systemic effects. Inhalation: Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects. Chronic: Effects may be delayed. Section 4 - FIRST AID MEASURES Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes). Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Discard contaminated shoes. Storage: Keep away from heat and flame. Keep refrigerated. (Store below 4C/39F.) Keep container closed when not in use. Corrosives area. Store in a cool, dry area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 12067-99-1: United Kingdom, WEL - TWA: (listed as tungsten, soluble compounds mg/m3 TWA (as W) United Kingdom, WEL - STEL: (listed as tungsten, soluble compound 3 mg/m3 STEL (as W) Belgium - TWA: (listed as tungsten, soluble compounds): 1 mg/m3 V (as W) Belgium - STEL: (listed as tungsten, soluble compounds): 3 mg/m3 (as W) Malaysia: (listed as tungsten, soluble compounds): 1 mg/m3 TWA (a Netherlands: (listed as tungsten, soluble compounds): 1 mg/m3 MAC W) Russia: (listed as tungsten): 6 mg/m3 TWA Spain: (listed as tungsten, soluble compounds): 1 mg/m3 VLA-ED (a Spain: (listed as tungsten, soluble compounds): 3 mg/m3 VLA-EC (a CAS# 12501-23-4: United Kingdom, WEL - TWA: (listed as tungsten, soluble compounds mg/m3 TWA (as W) United Kingdom, WEL - STEL: (listed as tungsten, soluble compound 3 mg/m3 STEL (as W) Belgium - TWA: (listed as tungsten, soluble compounds): 1 mg/m3 V (as W) Belgium - STEL: (listed as tungsten, soluble compounds): 3 mg/m3 (as W) Malaysia: (listed as tungsten, soluble compounds): 1 mg/m3 TWA (a Netherlands: (listed as tungsten, soluble compounds): 1 mg/m3 MAC W) Russia: (listed as tungsten): 6 mg/m3 TWA Spain: (listed as tungsten, soluble compounds): 1 mg/m3 VLA-ED (a Spain: (listed as tungsten, soluble compounds): 3 mg/m3 VLA-EC (a Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystals Color: white to cream Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 0 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: soluble Specific Gravity/Density: Not available. Molecular Formula: H3PO40W12.xH2O Molecular Weight: 2880.17 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: High temperatures, dust generation. Incompatibilities with Other Materials: Strong bases. Hazardous Decomposition Products: Phosphine, oxides of phosphorus. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 12067-99-1: TH5650000 CAS# 12501-23-4 unlisted. LD50/LC50: CAS# 12067-99-1: Oral, rat: LD50 = 3300 mg/kg. CAS# 12501-23-4. Carcinogenicity: Tungsten hydroxide oxide phosphate - Not listed by ACGIH, IARC, or NTP. Phosphotungstic Acid Hydrate, p.a. - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: CORROSIVE SOLID, ACIDIC, INORGANIC, N.O.S.* Hazard Class: 8 UN Number: 3260 Packing Group: III IMO Shipping Name: CORROSIVE SOLID, ACIDIC, INORGANIC, N.O.S. Hazard Class: 8 UN Number: 3260 Packing Group: III RID/ADR Shipping Name: CORROSIVE SOLID, ACIDIC, INORGANIC, N.O.S. Hazard Class: 8 UN Number: 3260 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 12067-99-1: No information available. CAS# 12501-23-4: No information available. Canada CAS# 12067-99-1 is listed on Canada's DSL List. CAS# 12067-99-1 is not listed on Canada's Ingredient Disclosure List. CAS# 12501-23-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 12067-99-1 is listed on the TSCA inventory. CAS# 12501-23-4 is not on the TSCA Inventory because it is a hydrate. It is considered to be listed if the CAS number for the anhydrous form is on the inventory (40CFR720.3(u)(2)). SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1. 急性毒性：大鼠口服LD50：3300mg/kg； 主要的刺激性影响： 在皮肤上面：刺激皮肤和粘膜 在眼睛上面：刺激的影响 致敏作用：没有已知的敏化现象 生态学数据: 通常对水体是稍微有害的，不要将未稀释或大量产品接触地下水，水道或污水系统，未经政府许可勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : TH5650000 CHEMICAL NAME : Phosphotungstic acid CAS REGISTRY NUMBER : 12067-99-1 LAST UPDATED : 199701 WISWESSER LINE NOTATION : .WO..O3 24 &..H3.P-O4 2 &QH48 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3300 mg/kg REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TUNGSTEN, soluble-air:10H TWA 1 mg(W)/m3;STEL 3 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81065 No. of Facilities: 867 (estimated) No. of Industries: 7 No. of Occupations: 8 No. of Employees: 8320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81065 No. of Facilities: 1413 (estimated) No. of Industries: 5 No. of Occupations: 14 No. of Employees: 26369 (estimated) No. of Female Employees: 19198 (estimated)

安全

• 危害码 (欧洲): C:Corrosive;
• 风险声明 (欧洲): R34
• 安全声明 (欧洲): 26-36/37/39-45-24/25
• 危险品运输编码: UN 3264 8/PG 2
• WGK德国: 3
• 包装等级: III
• 危险类别: 5.1
• 海关编码: 29159080

制备

由钨酸钠溶液中加磷酸和盐酸酸化后，以乙醚萃取而得。采用Rosenheim与Jaenicke的方法，磷钨酸是很容易制备的。将1000g钨酸钠（Na2WO4·2H2O）与160g磷酸氢二钠（Na2HPO4·2H2O）溶解在1500mL沸水中。在恒定的搅拌下将800mL的浓盐酸逐滴地加入其中。当加入一半的酸时开始有磷钨酸分离出来。由于沉淀出来的酸必须加以纯制，所以并不需要将它过滤出来。溶液冷却后，加入不含还原剂的乙醚，直到经摇荡后混合物分成三个液层为止。这样大约需要600mL的乙醚。如果必要时，可以加入一些水来将氯化钠溶解掉。底下液层是磷钨酸乙醚复合物，加水洗涤数次，每次加入足够的乙醚使形成第三液层。然后在乙醚液层中通入洗涤过不含尘埃的空气，使之蒸发结晶。过滤后，令晶体空敞地放在空气中，但勿使与尘埃接触，直到它们不再有乙醚的气味，依钨酸钠计算产率约为80%。

海关

海关编码	29159080