96829-59-3

• 常用中文名：奥利司他中间体
• 常用英文名：(-)-Lipstatin
• CAS号：96829-59-3
• 分子式：C₂₉H₄₉NO₅
• 分子量：491.70
• 发布时间：2018-04-02 08:00:00
• 更新时间：2024-01-10 18:41:48
• Lipstatin是一种非常有效的胰脂肪酶抑制剂,可从毒链霉菌中分离得到。Lipstatin抑制猪胰脂肪酶水解三油酸酯,IC50为0.14μM[1]。

名称

• 中文名: 奥利司他中间体
• 英文名: [(2S,4E,7E)-1-(3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl] (2S)-2-formamido-3-methylpentanoate
• 英文别名: L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester; (2S-(2alpha(1R*,3Z,6Z),3beta))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester; (2S,3S,5S,7Z,10Z)-5-[(S)-2-formamido-4-methyl-valeryloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic acid lactone; L-Leucine,N-formyl-,1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester,(2S-(2alpha(1R*,3Z,6Z),3beta)); (2S,3S,5S,7Z,1OZ)-5-[(S)-2-formamido-4-methyl-valeryloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic 1,3 acid lactone; (2S,4Z,7Z)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl N-formyl-L-leucinate; (2S-(2α(1R*,3Z,6Z),3β))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester; lipstatin; (-)-lipstatin; (2S,4Z,7Z)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]-4,7-tridecadien-2-yl N-formyl-L-leucinate; (2S-(2a(1R*,3Z,6Z),3b))-N-Formyl-L-leucine 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl Ester

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 627.4±55.0 °C at 760 mmHg
• 分子式: C₂₉H₄₉NO₅
• 分子量: 491.70
• 闪点: 333.2±31.5 °C
• 精确质量: 491.361084
• PSA: 81.70000
• LogP: 8.05
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.485

生物活性

• 描述: Lipstatin是一种非常有效的胰脂肪酶抑制剂,可从毒链霉菌中分离得到。Lipstatin抑制猪胰脂肪酶水解三油酸酯,IC50为0.14μM[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体内研究: Lipstatin(20、60mg/kg口服；单剂量；3.天)剂量依赖性地抑制三油酸甘油酯的吸收,而油酸在小鼠体内吸收正常[1]
• 参考文献:

  [1]. Weibel E K, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity[J]. The Journal of antibiotics, 1987, 40(8): 1081-1085.

合成路线

5338-45-4 108102-73-4 ~49% 96829-59-3

文献：Pons, Jean-Marc; Pommier, Agnes; Lerpiniere, Joan; Kocienski, Philip Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 14 p. 1549 - 1552

10340-23-5 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

31823-43-5 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

120018-49-7 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

85924-42-1 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

66-25-1 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

151509-74-9 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

151509-75-0 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

136695-81-3 ~% 96829-59-3

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552

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