(-)-Lipstatin
Modify Date: 2024-01-10 18:41:48
(-)-Lipstatin structure
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Common Name | (-)-Lipstatin | ||
|---|---|---|---|---|
| CAS Number | 96829-59-3 | Molecular Weight | 491.70 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 627.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C29H49NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 333.2±31.5 °C | |
Use of (-)-LipstatinLipstatin is a very potent pancreatic lipase inhibitor can be isolated from Streptomyces toxytricini. Lipstatin inhibits the hydrolysis of trioleate by porcine pancreatic lipase with an IC50 of 0.14 μM[1]. |
| Name | [(2S,4E,7E)-1-(3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl] (2S)-2-formamido-3-methylpentanoate |
|---|---|
| Synonym | More Synonyms |
| Description | Lipstatin is a very potent pancreatic lipase inhibitor can be isolated from Streptomyces toxytricini. Lipstatin inhibits the hydrolysis of trioleate by porcine pancreatic lipase with an IC50 of 0.14 μM[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Lipstatin（20、60 mg/kg；口服；单剂量；3 天）剂量依赖性地抑制三油酸甘油酯的吸收，而油酸在小鼠体内吸收正常[1]。 |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 627.4±55.0 °C at 760 mmHg |
| Molecular Formula | C29H49NO5 |
| Molecular Weight | 491.70 |
| Flash Point | 333.2±31.5 °C |
| Exact Mass | 491.361084 |
| PSA | 81.70000 |
| LogP | 8.05 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.485 |
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~49%
(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Pons, Jean-Marc; Pommier, Agnes; Lerpiniere, Joan; Kocienski, Philip Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 14 p. 1549 - 1552 |
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(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
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(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
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(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
|
~%
(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
|
~%
(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
|
~%
(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
|
~%
(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
|
~%
(-)-Lipstatin CAS#:96829-59-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 14 p. 1549 - 1552 |
![[(3Z)-3-nonen-1-yl]triphenylphosphonium bromide structure](https://www.chemsrc.com/caspic/085/85924-42-1.png)
![Methyl (R)-(Z,Z)-3-[(tert-butyldimethylsilyl)oxy]-5,8-tetradecadienoate structure](https://www.chemsrc.com/caspic/385/151509-75-0.png)
| Precursor 9 | |
|---|---|
| DownStream 0 | |
| L-Leucine, N-formyl-, (1S,3Z,6Z)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-3,6-dodecadien-1-yl ester |
| (2S-(2alpha(1R*,3Z,6Z),3beta))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester |
| (2S,3S,5S,7Z,10Z)-5-[(S)-2-formamido-4-methyl-valeryloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic acid lactone |
| L-Leucine,N-formyl-,1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester,(2S-(2alpha(1R*,3Z,6Z),3beta)) |
| (2S,3S,5S,7Z,1OZ)-5-[(S)-2-formamido-4-methyl-valeryloxy]-2-hexyl-3-hydroxy-7,10-hexadecadienoic 1,3 acid lactone |
| (2S,4Z,7Z)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl N-formyl-L-leucinate |
| (2S-(2α(1R*,3Z,6Z),3β))-N-Formyl-L-leucine 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl ester |
| lipstatin |
| (-)-lipstatin |
| (2S,4Z,7Z)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]-4,7-tridecadien-2-yl N-formyl-L-leucinate |
| (2S-(2a(1R*,3Z,6Z),3b))-N-Formyl-L-leucine 1-((3-Hexyl-4-oxo-2-oxetanyl)methyl)-3,6-dodecadienyl Ester |