78816-67-8

• 常用中文名：[5-[(二甲氨基)乙酰基]-10,11-二氢-5H-二苯并[B,F]氮杂革-3-基]氨基甲酸乙酯单盐酸盐
• 常用英文名：Bonnecor
• CAS号：78816-67-8
• 分子式：C₂₁H₂₆ClN₃O₃
• 分子量：403.90200
• 发布时间：2019-01-01 16:05:10
• 更新时间：2026-07-19 19:51:31

名称

• 中文名: [5-[(二甲氨基)乙酰基]-10,11-二氢-5H-二苯并[B,F]氮杂革-3-基]氨基甲酸乙酯单盐酸盐
• 英文名: Bonnecor
• 中文别名: 盐酸替拉西秦; 盐酸替拉西嗪
• 英文别名: TIRACIZINEHYDROCHLORIDE; Tiracizine Hydrochioride; Cbamic acid, (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(B,F)azin-3-yl)-, ethyl ester, monohydrochloride; 3-Cbethoxyamino-5-dimethylaminoacetyl-10,11-dihydrodibenz(B,F)azine hydrochloride; AWD-19-166; 3-Carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyle-Hydrochlorid; Tiracizine HCl; 5H-Dibenz(B,F)azine-3-cbamic acid, 10,11-dihydro-5-((dimethylamino)acetyl)-, ethyl ester,monohydrochloride; [5-[(dimethylamino)acetyl]-10，11-dihydro-5H-dibenz[b，f]azin-3-y1]cabamic acid ethyl ester monohydrochloride; Carbamic acid,(5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(B,F)azepin-3-yl)-,ethyl ester,monohydrochloride; Ethyl (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(B,F)azepin-3-yl)carbamate monohydrochloride; 5H-Dibenz(B,F)azepine-3-carbamic acid,10,11-dihydro-5-((dimethylamino)acetyl)-,ethyl ester,monohydrochloride; 3-Carbethoxyamino-5-dimethylaminoacetyl-10,11-dihydrodibenz(B,F)azepine hydrochloride; GS-015; Ethyl (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(B,F)azin-3-yl)cbamate monohydrochloride

物化性质

• 沸点: 525.3ºC at 760 mmHg
• 分子式: C₂₁H₂₆ClN₃O₃
• 分子量: 403.90200
• 闪点: 271.5ºC
• 精确质量: 403.16600
• PSA: 61.88000
• LogP: 4.51990

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HN8110000 CHEMICAL NAME : 5H-Dibenz(b,f)azepine-3-carbamic acid, 10,11-dihydro-5-((dimethylamino)acetyl)-, ethyl ester, monohydrochloride CAS REGISTRY NUMBER : 78816-67-8 LAST UPDATED : 199803 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C21-H25-N3-O3.Cl-H MOLECULAR WEIGHT : 403.95 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10900 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 48 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5400 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 40,871,1985

合成路线

83275-56-3 ~% 78816-67-8

文献：Wunderlich; Stark; Carstens; Lohmann; Grizenko; Skoldinov Pharmazie, 1985 , vol. 40, # 12 p. 827 - 830

10464-35-4 ~% 78816-67-8

文献：Wunderlich; Stark; Carstens; Lohmann; Grizenko; Skoldinov Pharmazie, 1985 , vol. 40, # 12 p. 827 - 830

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