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15387-10-7

15387-10-7结构式

常用中文名：烟丙法宗
常用英文名：N-[[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-propan-2-ylamino]methyl]pyridine-3-carboxamide
CAS号：15387-10-7
分子式：C₂₁H₂₅N₅O₂
分子量：379.45600
发布时间：2018-06-20 11:28:29
更新时间：2024-01-10 15:11:21

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中文名	烟丙法宗
英文名	N-[[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-propan-2-ylamino]methyl]pyridine-3-carboxamide
英文别名	Ra 101 (pharmaceutical) Niprofazonum [INN-Latin] 1-Phenyl-2,3-dimethyl-4(N-nicotinamidomethyl-N-isopropyl)amino-5-pyrazolone Nicotinamide,N-((antipyrinylisopropylamino)methyl) Nicotinamidomethylaminopyrazolone Niprofazona [INN-Spanish] Niprofazone RA 101 N-{[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-isopropyl-amino]-methyl}-nicotinamide N-((Antipyrinylisopropylamino)methyl)nicotinamide

密度	1.25g/cm3
分子式	C₂₁H₂₅N₅O₂
分子量	379.45600
精确质量	379.20100
PSA	72.16000
LogP	2.87260
折射率	1.638
储存条件	库房通风低温干燥

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QS4025000

CHEMICAL NAME :: Nicotinamide, N-((antipyrinylisopropylamino)methyl)-

CAS REGISTRY NUMBER :: 15387-10-7

BEILSTEIN REFERENCE NO. :: 0766712

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C21-H25-N5-O2

MOLECULAR WEIGHT :: 379.51

WISWESSER LINE NOTATION :: T6NJ CVM1NY1&1&- DT5NNVJ A1 BR& E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 853 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1024,1970